Large conductance Ca(2+)-activated K(+) channels (BK(Ca)) play a critical role in blood pressure regulation by tuning the vascular smooth muscle tone, and hyposensitivity of BK(Ca) to Ca(2+) sparks resulting from its altered beta1 subunit stoichiometry underlies vasoconstriction in animal models of hypertension. Here we demonstrate hypersensitivity of BK(Ca) to Ca(2+) sparks that contributes to...

Ca(2+) sparks are highly localized, transient releases of Ca(2+) from sarcoplasmic reticulum through ryanodine receptors (RyRs). In smooth muscle, Ca(2+) sparks trigger spontaneous transient outward currents (STOCs) by opening nearby clusters of large-conductance Ca(2+)-activated K(+) channels, and also gate Ca(2+)-activated Cl(-) (Cl((Ca))) channels to induce spontaneous transient inward curre...

Research on hydraulic turbines, regardless of type, has shown that all materials used in the manufacture parts are components flow path, working same conditions, subject to hydro-abrasive wear, different proportions. The most attacked blades and chambers turbines. In this paper studied construction turbine have been previously deposited by method electro-spark deposition with tungsten carbide (...

among the most common types of problematic soils, are probably the expansive ones. one of the modern methods of strengthening and improving the soil in place is the use of electro-osmotic improving treatment. this paper presents the design of an apparatus suitable for electro-osmotic treatment. a soil sample of a high expansive potential was compacted and the effect of electro-osmotic treatment...

Summary This paper proposes TRANSMUT‐Spark for automating mutation testing of big data processing code within Spark programs. Apache is an engine analytics/processing that hides the inherent complexity parallel programming. Nonetheless, programmers must cleverly combine built‐in functions programs and guide to use right management strategies exploit computational resources required by avoid sub...

Spark plasma sintering (SPS) is a highly efficient method for the preparation of α/β-SiAlON ceramics. However, rapid large-scale ceramic components with reliable mechanical properties difficult via SPS due to their near-insulating properties. In this study, high-performance end mill rods large aspect ratios were successfully prepared SPS. Two different types processes (namely vertical-round-rod...

In this work it was shown that the inactivation micromycets spore (fungi) to hot plasma radiation of self-sustained spark discharge on air is much more effectively than UVradiation mercury-vapor lamp. Though the discharge electrical power is 15 times and UVphotons flux 430 times more for mercury lamp than for spark discharge. Discussed method inactivation is very simple.

For a measurement matrix in compressed sensing, its spark (or the smallest number of columns that are linearly dependent) is an important performance parameter. The matrix with spark greater than 2k guarantees the exact recovery of ksparse signals under an l0-optimization, and the one with large spark may perform well under approximate algorithms of the l0-optimization. Recently, Dimakis, Smara...

The need for modern data analytics to combine relational, procedural, and map-reduce-style functional processing is widely recognized. State-of-the-art systems like Spark have added SQL front-ends and relational query optimization, which promise an increase in expressiveness and performance. But how good are these extensions at extracting high performance from modern hardware platforms? While S...

This paper introduces GeoSpark an in-memory cluster computing framework for processing large-scale spatial data. GeoSpark consists of three layers: Apache Spark Layer, Spatial RDD Layer and Spatial Query Processing Layer. Apache Spark Layer provides basic Spark functionalities that include loading / storing data to disk as well as regular RDD operations. Spatial RDD Layer consists of three nove...