The interest in the detection and quantification of S-nitrosothiols or thionitrites RSNOs in biological media and their use as pharmaceutical agents is mainly related to the discovery of nitric oxide as an endothelium relaxing factor, and analytical methodologies that are able to detect these moieties in real time, in situ and ideally with high sensitivity and selectivity could help in a better...

Xiaona Fang , Qiong Liu, Christopher Bohrer, Zach Hensel,Wei Han, Jin 3 Wang *, Jie Xiao * 4 State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of 5 Applied Chemistry, Changchun, China. 6 Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of 7 Medicine, Baltimore, Maryland, USA. 8 College of Physics, Jilin University, Changchun, China. 9 Department of...

Even though significant progress has been made in the development of electrodes for the in vivo detection of catecholamines, oxygen, and various cations, there has been little research on the feasibility of continuously monitoring drugs in whole blood by electrochemical sensing devices. Electroanalytical problems associated with the development of such electrochemical transducers include the ne...

The surface of an electrochemical glassy carbon electrode was modified with a layer of double-stranded DNA (dsDNA) or with double-stranded DNA conditioned in single-stranded DNA (ssDNA) and was used to investigate mitoxantrone-DNA interactions. Differential pulse and square wave voltammetry were applied to develop an electroanalytical procedure for the determination of mitoxantrone and evaluate...

Abstract Aleksandr Il’ich Glazunov developed the first electrochemical technique to image surface of conducting solids giving name electrography. The electrographic images can mirror distribution elements on solid materials and also activity, caused by variations “dissolution tension”. Thus, he has established for time a kind spatially resolved electrochemistry. Electrography is direct electroa...

Physicochemical and electrochemical characterization of carbon films obtained by pyrolyzing a commercially available photoresist has been performed. Photoresist spin-coated on to a silicon wafer was pyrolyzed at 1,000 degrees C in a reducing atmosphere (95% nitrogen and 5% hydrogen) to produce conducting carbon films. The pyrolyzed photoresist films (PPF) show unusual surface properties compare...

Here, we report the use of microwire and mesh working electrodes in paper analytical devices fabricated by origami paper folding (oPADs). The important new result is that Au wires and carbon fibers having diameters ranging from micrometers to tens of micrometers can be incorporated into oPADs and that their electrochemical characteristics are consistent with the results of finite element simula...

The first and most important step in the development and manufacture of a sensitive DNA-biosensor for hybridization detection is the immobilization procedure of the nucleic acid probe on the transducer surface, maintaining its mobility and conformational flexibility. MAC Mode AFM images were used to demonstrate that oligonucleotide (ODN) molecules adsorb spontaneously at the electrode surface. ...