نتایج جستجو برای: electronic disequilibrium
تعداد نتایج: 234933 فیلتر نتایج به سال:
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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies to a wide range of self-antigens. Recent genome screens have implicated numerous chromosomal regions as potential SLE susceptibility loci. Among these, the 1q41 locus is of particular interest, because evidence for linkage has been found in several independent SLE family collecti...
Computer simulations were performed with overdominant muliple alleles among tightly linked multiple loci under a multiplicative fitness model. The quantity chi2/N (n--1) was introduced as a new measure of linkage disequilibrium which, unlike previously available measures, can be applied to multiple allele models, where N is the sample size, and n is the number of alleles at the locus possessing...
Recent geochemical studies of MORB genesis suggest that at least some degree of chemical disequilibrium occurs during the transport of magma to the surface. If disequilibrium transport does occur in the mantle, it would seem to preclude melt being distributed in a porous network on grain boundaries that could rapidly re-equilibrate with the solid. The questions remain however, as to how big a m...
We propose a new method for family-based tests of association and linkage called transmission/disequilibrium tests incorporating unaffected offspring (TDTU). This new approach, constructed based on transmission/disequilibrium tests for quantitative traits (QTDT), provides a natural extension of the transmission/disequilibrium test (TDT) to utilize transmission information from heterozygous pare...
BACKGROUND/OBJECTIVE The analysis of linkage disequilibrium is relevant for the exploration of the structure and evolution of genomes and for the gene mapping of quantitative characters and human diseases. The strength of linkage disequilibrium between diallelic loci is commonly measured by the coefficients D' and r. Recent studies suggest that r is more useful than D' as a general measure of t...
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