TAP1/TAP2 complexes translocate peptides from the cytosol to the endoplasmic reticulum lumen to enable immune surveillance by CD8(+) T cells. Peptide transport is preceded by peptide binding to a cytosol-accessible surface of TAP1/TAP2 complexes, but the location of the TAP peptide-binding pocket remains unknown. Guided by the known contributions of polymorphic TAP variants to peptide selection...

We prototyped two selection techniques, Point-Tap and Tap-Tap, and conducted experiments to assess their characteristics, in particular how familiarity with a space affects their usability. Both techniques were developed to enhance the capability of the general ”pointing gesture” and ”map with live video” techniques. The goal of both techniques is to acquire a target object in smart space, and ...

Scalds from hot tap water are serious injuries that are potentially preventable by restricting the temperature of hot tap water delivery. In July 1999, regulations were introduced in NSW to require that all new hot water installations deliver water at temperatures not exceeding 50 degrees C to sanitary fixtures. This study investigates trends in hot tap water scald injury hospitalisations follo...

Cytotoxic T-lymphocytes play an important role in the protection against viral infections, which they detect through the recognition of virus-derived peptides, presented in the context of MHC class I molecules at the surface of the infected cell. The transporter associated with antigen processing (TAP) plays an essential role in MHC class I-restricted antigen presentation, as TAP imports peptid...

TAP translocates virus-derived peptides from the cytosol into the endoplasmic reticulum, where the peptides are loaded onto MHC class I molecules. This process is crucial for the detection of virus-infected cells by CTL that recognize the MHC class I-peptide complexes at the cell surface. The varicellovirus bovine herpesvirus 1 encodes a protein, UL49.5, that acts as a potent inhibitor of TAP. ...

The Tap (taxis toward peptides) receptor and the periplasmic dipeptide-binding protein (DBP) of Escherichia coli together mediate chemotactic responses to dipeptides. Tap is a low-abundance receptor. It is present in 5- to 10-fold-fewer copies than high-abundance receptors like Tar and Tsr. Cells expressing Tap as the sole receptor, even from a multicopy plasmid at 5- to 10-fold-overexpressed l...

This paper proposes a method to improve the fractional interpolation of reference samples in Versatile Video Coding (VVC) intra prediction. The proposed uses additional filters which use more integer-positioned for prediction according frequency information samples. In VVC, 4-tap Discrete Cosine Transform-based filter (DCT-IF) and Smoothing (SIF) are alternatively performed on block size direct...

INTRODUCTION   The transversus abdominis plane (TAP) local anaesthetic block is beneficial in patients undergoing open pelvic surgery; however, there are no data on its use in women undergoing laparoscopic gynaecologic surgery. METHODS   Successive women undergoing TLH were included in this review. All women had local anaesthetic infiltration at the site of port placement and, in addition, re...

The transformers which connect the different voltage levels in transmission and distribution systems are supplied with on-load tap changing mechanism. The on-load tap changer maintains the voltage amplitude within the predefined limits at the so called regulation bus. In a radial feeder, the on-load tap changers are cascaded. Poor coordination between cascaded tap changers causes improper volta...