background & aim:parkinson's disease (pd) is a kind of disorder in the nervous system, which is characterized with multiple movement disorders. factors such as oxidative stress are the most important causes for the degeneration of dopaminergic neurons in the substantia nigra and occurrence of parkinson's disease. thus, medications that have antioxidant functions could be an interestin...

Parkinson disease is a progressive degenerative disease causing motor and non-motor symptoms. Sleep disturbance is a common non-motor symptom and significantly affect the day to day activities of patients and their quality of life. Though common, sleep disturbance is an under diagnosed feature of Parkinson disease (PD). Night-time sleep disturbances have been reported in as many as 60 to 98% of...

Mutations in the the leucine-rich repeat kinase-2 (LRRK2) gene cause autosomal-dominant Parkinson disease and some cases of sporadic Parkinson disease. Here we found that LRRK2 kinase activity was regulated by GTP via the intrinsic GTPase Roc domain, and alterations of LRRK2 protein that reduced kinase activity of mutant LRRK2 correspondingly reduced neuronal toxicity. These data elucidate the ...

whole body vibration (wbv) is a contemporary treatment modality that holds promise as an exercise training method in health–compromised individuals. a growing number of studies on individuals with parkinson disease are examining whether wbv improves balance and functional mobility. however, interpreting wbv studies is challenging since there is variability in the manner in which wbv interventio...

Antioxidants have protective effects against free radicals-induced neural damage in Parkinson's disease (PD). We examined the effects of ellagic acid (EA) on locomotion, pallidal local EEG, and its frequency bands' power and also cerebral antioxidant contents in a rat model of PD induced by 6-hydroxidopamine (6-OHDA). 6-OHDA (16 µg/2µ l) was injected into the right medial forebrain bundle (MFB)...

A Doença de Parkinson (DP) tem como fisiopatologia a disfunção neurotransmissores, principalmente perda progressiva dos neurônios dopaminérgicos da porção compacta substância negra, que exerce importante função no controle motor do indivíduo. O projeto extensão “Assistência Fisioterapêutica em Grupo para Indivíduos com Parkinson” (AGruPar) propósito realizar atendimentos grupo indivíduos diagno...

The objective of this study was to determine whether hypothyroidism is more common in Parkinson patients than in a control group without Parkinson, as suggested in the past. We performed a retrospective file review of all admissions to the geriatric ward during a 1-year period. Concentrations of thyroid stimulating hormone (TSH) and thyroxine (T4) from 92 Parkinson patients were compared with t...

OBJECTIVES To estimate the impact of ellagic acid (EA) towards healing tooth socket in diabetic animals, after tooth extraction. METHODS Twenty-four Sprague Dawley male rats weighing 250-300 g were selected for this study. All animals were intraperitoneally injected with 45 mg/kg (b.w.) of freshly prepared streptozotocin (STZ), to induce diabetic mellitus. Then, the animals were anesthetized,...