Ocimum basilicum L. is the most common species, and it used as an ornamental plant in food condiments. This unique study examined chemical composition biological activities of six extracts from five basil cultivars, including their antimicrobial, antidiabetic, antilipidemic, neuroprotective, anticollagenase activity. Moreover, toxicological effects were studied using zebrafish Danio rerio. Vola...

Dasatinib is a targeted cancer therapy, while programmed death ligand 1 (PD-L1) inhibitors are form of immune checkpoint therapy used to treat various types cancers. Several studies showed the potential efficacy these drugs in management triple-negative breast cancer- an aggressive subtype cancer, which can develop during pregnancy. Nevertheless, side effects (DA) and PD-L1 pregnancy, especiall...

Objective Methotrexate (MTX), as an anti-folate agent, is widely used in the treatment of rheumatic disorders and malignant tumors, however it damages reproductive system in mice. The aim of this research was to study the effects of ethyl pyruvate (EP) on embryo development and oxidative stress changes in the testis of mice treated with MTX. MaterialsAndMethods In this experimental study, thirt...

Vertebrate embryos are particularly sensitive to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Identification of tissues that are susceptible to the adverse effects of TCDD is requisite for understanding the embryo toxic effects of TCDD. The objective of the present study was to quantitate the temporal appearance of and dose dependence of apoptosis in TCDD-exposed medaka embryos (Oryzias latipes)...

BACKGROUND Cells respond to adverse environmental stimuli by enhancing the expression of specific genes, the products of which include a suite of proteins known as heat shock proteins (hsps), a response often attributed to cellular protection. METHODS In this study, we characterized alterations in hsp expression in chick embryos (Hamburger-Hamilton stage 17, 72 h) exposed in ovo to arsenite (...

The embryotoxicity and teratogenicity of cadmium chloride (CdCl2) were tested by the FETAX (Frog Embryo Teratogenesis Assay: Xenopus) procedure in the South African frog, Xenopus laevis. In five assays, groups of Xenopus embryos were grown in media that contained CdCl2 at concentrations ranging from 0.75 to 56 mumol per L; control groups were incubated in the same medium without added CdCl2. Th...

The embryonic stem cell test (EST) is an in vitro assay that has been developed to assess the embryotoxic potential of chemicals and biomaterials. It is based on the capacity of the mouse embryonic stem cell line D3 (ES-D3 cells) to differentiate into contracting myocardial cells. However, the EST method cannot fully test the embryotoxicity of mercury vapor. We tried to apply the rotary culture...

Embryotoxicity and Fetotoxicity of Inhaled or Ingested Vinylidene Chloride in Rats and Rabbits. MURRAY, F. J., NITSCHKE, K. D., RAMPY, L. W., AND SCHWETZ, B. A. (1979). Toxicol. App/. Pharmacal. 49, 189-202. The teratogenic potential of inhaled or ingested vinylidene chloride was evaluated in Sprague-Dawley rats and New Zealand white rabbits. Both species were exposed to the test material by in...