Recently, we reported that exogenous administration of Met(5)-enkephalin (ME) for 24 h reduces infarct size after ischemia-reperfusion in rabbits. In the present study, we tested whether ME-induced cardioprotection is exhibited in murine hearts and whether chronic infusion of this peptide can render hearts tolerant to ischemia. Barbiturate-anesthetized open-chest mice (C57BL/6J) were subjected ...

Current management of glaucoma entails the medical, laser, or surgical reduction of intraocular pressure (IOP) to a predetermined level of target IOP, which is commensurate with either stability or delayed progression of visual loss. In the published literature, the hypothesis is often made that IOP control implies a single IOP measurement over time. Although the follow-up of glaucoma patients ...

A Hybrid Partitioned Frequency/Time domain adaptive filtering algorithm for vibration shock control is proposed. Due to the complexity of the electrodynamic shaker transfer function, the FIR based model of this transfer function requires thousands of filter weights. The Hybrid Partitioned Frequency/Time domain approach for computing the shaker model and inverse controller model is proposed, suc...

We studied the structure of the C terminus of the Shaker potassium channel. The 3D structures of the full-length and a C-terminal deletion (Delta C) mutant of Shaker were determined by electron microscopy and single-particle analysis. The difference map between the full-length and the truncated channels clearly shows a compact density, located on the sides of the T1 domain, that corresponds to ...

Abstract Correcting the forecast bias of numerical weather prediction models is important for severe warnings. The refined grid requires direct correction on gridded products, as opposed to correcting data only at individual stations. In this study, a deep learning method called CU-net proposed correct forecasts four variables from European Centre Medium-Range Weather Forecast Integrated Foreca...