Vascular endothelial growth factor (VEGF) is a potent promoter of angiogenesis involved in a wide variety of physiologic processes. Intravitreal injections targeting VEGF have transformed the treatment of neovascular retinal diseases. Currently, there are four anti-VEGF agents in use: bevacizumab, ranibizumab, pegaptanib, and aflibercept. The success and frequency of anti-VEGF therapy have made...

The objective of this study was to evaluate the microbiological spectrum and antimicrobial susceptibility of isolates in delayed post-cataract surgery endophthalmitis. A retrospective review of 33 consecutive patients with culture proven delayed post-cataract surgery endophthalmitis was done from January 2006 to March 2013. There were 22 bacterial and eleven fungal cases. Common isolates were S...

PURPOSE We describe a patient with endogenous endophthalmitis caused by Acinetobacter spp. as the first clinical presentation of diabetes mellitus. METHOD A 48-year-old otherwise healthy woman was referred with signs and symptoms of acute endophthalmitis in the left eye. Systemic work-up, vitreous tap, and intravitreal antibiotic injection were performed followed by pars plana vitrectomy. R...

Endophthalmitis is an uncommon but often visually devastating complication of intravitreal injections. This commentary reviews the key aspects and technical components of intravitreal injections and how they may relate to the development of endophthalmitis. Because endophthalmitis is a rare event, data are often lacking on specific aspects of injection technique that may or may not be helpful i...

BACKGROUND We report the case of an 81-year-old woman with a history of radial keratotomy 9 years prior who developed endophthalmitis without preceding keratitis 4 days after uneventful photorefractive keratectomy surgery. This case report utilized clinical examination and microbacterial laboratory findings. FINDINGS Diagnosis of bacterial endophthalmitis was made via clinical examination and...

Endophthalmitis is an intraocular inflammation involving both posterior and anterior segments, caused by bacterial or fungal infections. Here, we present a case series of five cases presented to the National Referral Hospital from January December 2017. Five eyes were identified, including exogenous endogenous odontogenic causes. All managed with vitrectomy, intravitreal antibiotics, systemic a...

INTRODUCTION The aim of this paper was to describe the use of r-TPA for fibrin clot dissolution following endophthalmitis. CLINICAL PICTURE A 74-year-old man presented with painful loss of vision following routine uncomplicated cataract surgery. TREATMENT He underwent standard treatment for postoperative endophthalmitis but despite this, developed a dense fibrin clot. He underwent further i...

PURPOSE To highlight good visual outcome with intravitreal amikacin administered 18 days following trauma-inducing vancomycin resistant enterococcal endophthalmitis treated initially with vitrectomy and oral linezolid. OBSERVATIONS Despite initial vitrectomy, intravitreal vancomycin, ceftazidime and oral linezolid, smoldering vitreous infiltrates prompted treatment with intravitreal amikacin ...

Endogenous fungal endophthalmitis (EFE) is a rare but serious complication of fungal sepsis and the incidence has increased in the past half century because of the advent of antibiotics and indwelling catheters [1]. The most common cause of culture-proven EFE is Candida species [2]. Although a particular therapeutic regimen has not been prospectively established, treatment options can include i...

Purpose To report the clinical course and treatment strategies employed in management of a case multidrug-resistant Pseudomonas aeruginosa keratitis progressing to endophthalmitis. The drug-resistant strain was later traced use contaminated EzriCare Artificial Tears multi-state cluster outbreak. Observations A 57-year-old male patient with history Descemet stripping automated endothelial kerato...