Scanning optical coherence tomography (OCT) is limited in sensitivity and resolution by the restricted focal depth of the confocal detection scheme. Holoscopy, a combination of holography and Fourier-domain full-field OCT, is proposed as a way to detect photons from all depths of a sample volume simultaneously with uniform sensitivity and lateral resolution, even at high NAs. By using the scala...

We demonstrate an application of high-speed swept source optical coherence tomography for vessel visualization in the anterior segment of the human eye. The human corneo-scleral junction and sclera was imaged in vivo. Imaging was performed using a swept source OCT system operating at the 1050nm wavelength range and 100kHz A-scan rate. High imaging speed enables the generation of 3D depth-resolv...

In this study, we propose a novel implementation of optical coherence tomography-based angiography combined with ex vivo perfusion of fixed hearts to visualize coronary microvascular structure and function. The extracorporeal perfusion of Intralipid solution allows depth-resolved angiographic imaging, control of perfusion pressure, and high-resolution optical microangiography. The imaging techn...

BACKGROUND No reports exist concerning in vivo optical coherence tomography visualization of the epidural space and the blood patch process in the epidural space. In this study, we produced real-time two-dimensional and reconstructed three-dimensional images of the epidural space by using optical coherence tomography in a porcine model. We also aimed to produce three-dimensional optical coheren...

Optical coherence tomography (OCT) is a real-time optical imaging technique that is similar in principle to ultrasonography, but employs light instead of sound waves and allows depth-resolved images with near-microscopic resolution. Endoscopic OCT allows the evaluation of broad-field and subsurface areas and can be used ancillary to standard endoscopy, narrow band imaging, chromoendoscopy, magn...

purpose: to determine the effect of induced myopia and hyperopia using soft contact lenses on optic disc parameters measured by fourier domain optical coherence tomography (fd-oct) in emmetropic persons. methods: in a quasi-experimental self controlled study, 57 normal emmetropic participants 18-42 years of age were studied. each subject underwent a complete ophthalmic examinations including me...

purpose : evaluating the effects of memantine on visual function after scleral buckling for rhegmatogenous retinal detachment (rrd) methods : in a double blind prospective randomized clinical trial, 61 patients with clinical diagnosis of less than 4 weeks macula-off rrd who had successful scleral buckle surgery had been selected and divided into two randomized groups. thirty of them received 5 ...

s and Conference Proceedings X. Li, T. H. Ko, and J. G. Fujimoto, “Intraluminal fiber optic Doppler imaging catheter for structural andfunctional optical coherence tomography,” Photonics West, SPIE, San Jose, CA, January 19-25, 2002,paper 4619-22. T. H. Ko, I. Hartl, W. Drexler, R. K. Ghanta, and J. G. Fujimoto, “Ultrahigh resolution optical coherencetomography for quantitative topo...

Aberrations in optical microscopy reduce image resolution and contrast, and can limit imaging depth when focusing into biological samples. Static correction of aberrations may be achieved through appropriate lens design, but this approach does not offer the flexibility of simultaneously correcting aberrations for all imaging depths, nor the adaptability to correct for sample-specific aberration...

Spectroscopic optical coherence tomography (spectroscopic OCT) is an echographic-like optical method for biomedical functional imaging. Current spectroscopic optical coherence tomography (OCT) methods rely on a posteriori numerical calculation. We present an alternative for optically accessing the spectroscopic information in OCT, that is, without postprocessing, by using a grating-based correl...