Enrofloxacin (ENR) is a broad-spectrum fluoroquinolone antibiotic widely used in both human medicine and veterinary medicine. In this study, the milk-excretion patterns of ENR its metabolite ciprofloxacin (CIP) were determined up to 10th milking following intramuscular administration (2.5mg/kg body weight) lactating dairy buffaloes. The milk each animal was collected concentrations CIP detected...

Enrofloxacin (ENR) is an antimicrobial agent belonging to the group of third-generation fluoroquinolones (FQs) [1,2]. ENR has been historically used as veterinary medicine for treatment of gastrointestinal and respiratory infections in several animal species, including pigs cursing diseases caused by gram-positive and negative bacteria. In animals, ENR is de-ethylated to its primary metabolite ...

The majority of Salmonella strains isolated in veterinary laboratories in Poland in 2001 originated from poultry (82%), swine (4%), and animal feeding stuffs (10%). Thirty-two serovars were observed among tested strains. Antimicrobial susceptibility testing revealed the recent trends in Salmonella resistance. The increase in the number of resistant strains was observed. Multiresistance occurred...

The aim of the present study was to determine whether the residual area under the curve (AUC(res%); expressed as % of total value of AUC) could be used as a parameter for the qualitative evaluation of pharmacokinetic studies.We propose new criteria for the qualitative evaluation of pharmacokinetic analysis. Two sets of hypothetical data that illustrate the relationship between concentration and...

Enteropathogenic Escherichia coli (EPEC) is the most important cause of persistent diarrhea in children, particularly in developing countries. Animals serve as pathogenic E. coli reservoirs, and compelling evidence for cross-species EPEC transmission exists. In this report, enzootic EPEC infection associated with up to 10.5% diarrhea-associated morbidity in a large laboratory Dutch Belted rabbi...

Efficient methods are needed for analysis of veterinary drug residues in food. A number of methods are available for single analytes. Multiresidue methods are now increasingly available. It is still rare, however, to find methods not involving mass spectrometry which allow for analysis of more than one class of drug residue. An efficient multiresidue method for the simultaneous determination of...

Campylobacter species cause 1.4 million infections each year in the United States. Fluoroquinolones (e.g., ciprofloxacin) are commonly used in adults with Campylobacter infection and other infections. Fluoroquinolones (e.g., enrofloxacin) are also used in veterinary medicine. Human infections with fluoroquinolone-resistant Campylobacter species have become increasingly common and are associated...