Sortase A inhibition is a well establish strategy for decreasing bacterial virulence by affecting numerous key processes that control biofilm formation, host cell entry, evasion and suppression of the immune response and acquisition of essential nutrients. A meta-analysis of structures known to act as Sortase A inhibitors provided the starting point for identifying a new potential scaffold. Bas...

Background: Surgical endodontic therapy is the prescribed treatment of choice whenever the non-surgical options fail which includes the use of a root end filling material. E. faecalis is the most prevalent organism associated with the treatment failed cases Aim: The purpose of the present study was to evaluate and compare the antimicrobial efficacy of Biodentine and MTA as root end filling mate...

objective: in this study, antimicrobial activities of an ethanol extract of tribulus terrestris aloneand in combination with capsella bursa-pastoris and glycyrrhiza glabra were examined in vitro against six pathogens namely streptococcus mutans, streptococcus sanguis, actinomyces viscosus, enterococcus faecalis staphylococcus aureus, and escherichia coli. materials and methods: antibacterial ac...

BACKGROUND Design and synthesis of pyrazole-dimedone derivatives were described by one-pot multicomponent reaction as new antimicrobial agents. These new molecular framework were synthesized in high yields with a broad substrate scope under benign conditions mediated by diethylamine (NHEt2). The molecular structures of the synthesized compounds were assigned based on different spectroscopic tec...

INTRODUCTION Due to the complex anatomy of the root canal system and high surface tension of common root canal irrigants (RCI), conducting an investigation on RCIs containing surfactants is a priority. The aim of this in vitro study was to verify the antibacterial potential of RCI with low surface tension in root canals infected with Enterococcus faecalis (E. faecalis). METHODS AND MATERIALS ...

The volatile compounds from Maclura pomifera (Osage orange fruit) peel have been studied by GC-FID and GC–MS. Volatiles fraction proportion was estimated to 60 mg/kg. Identified compounds consist on aliphatics (52.6%), monoterpenes along with sesquiterpenes (27.3%), phenylpropane derivatives along with related compounds (10.0%) and other compounds (10.6%). Among the 60 identified compounds, 1-h...

Nosocomial infection caused by methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococci (VRE) has become a great deal of recent concern. Although a number of cephalosporins had been synthesized in the past, few of them was effective against these resistant bacteria. Recently, TOC-39and TOC-50^3) bearing vinyl-thio linkage attached by substituted pyridines at C-3 we...

The present study aimed to evaluate optimize the growth and antibacterial activity of endophytic fungi isolated from Tylophora indica. Based on the morphological and molecular characteristic, the isolate was identified as Fusarium solani. Modified liquid medium (M2D) was used as a basal medium for growth and antibacterial activity. The growth and metabolite production were optimized with 4% dex...

AIM The purpose of this study was to test a new root canal sealer (Epiphany) and 5 other root canal sealers (Diaket, Endomethasone, AH 26, Sealapex, Sultan) for their antimicrobial effect on Enterococcus faecalis. MATERIALS AND METHODS The antimicrobial effect of 6 root canal sealers was tested by the agar diffusion method. The freshly mixed sealers were placed in prepared wells of agar plate...

STATEMENT OF THE PROBLEM Hydrogen peroxide (H2O2) has been suggested to be used in sequence or in combination with chlorhexidine (CHX) to enhance the antibacterial activity against Enterococcus faecalis, but there is no research in the literature on the safety and effectiveness of this irrigation protocol. PURPOSE This study aimed to assess the cytocompatibility and antibacterial activity of ...