OBJECTIVE This prospective study was designed to elucidate the duration of systemic inflammatory response syndrome (SIRS) and the mechanisms that lead to the protraction of SIRS in patients who are operated on under cardiopulmonary bypass (CPB). METHODS The duration of SIRS in 13 patients with SIRS was studied. Two groups were divided according to the duration to investigate the meaning of th...

Soluble immune response suppressor (SIRS), a lymphokine that suppresses antibody production and delayed type hypersensitivity in vivo, has been detected in urine and serum from certain patients with nephrotic syndrome. In the present paper, the relationship between SIRS production and nephrotic syndrome is further characterized. A striking correlation was found between detection of SIRS and the...

Abstract Background Many early warning scores (EWSs) have been validated to prognosticate adverse outcomes secondary sepsis in the Emergency Department (ED). These EWSs include Systemic Inflammatory Response Syndrome criteria (SIRS), quick Sequential Organ Failure Assessment (qSOFA) and National Early Warning Score (NEWS). However, Rapid Medicine (REMS) has never for this purpose. We aimed asse...

Patients with minimal change nephrotic syndrome (MCNS) frequently have suppressed in vivo and in vitro immune responsiveness of uncertain etiology. Because increased suppressor cell activity has been associated with this disease, urines from MCNS patients were screened for activity of the lymphokine soluble immune response suppressor (SIRS), a product of concanavalin A- or interferon-activated ...

BACKGROUND In accordance with the 1st International pediatric sepsis consensus conference, where sepsis was defined as SIRS associated with suspected or proven infection, we have identified the need to assess the prevalence of SIRS and sepsis in children with abnormal temperatures hospitalized in The Children's Clinical University Hospital in Latvia. METHODS A descriptive prospective point pr...

Babesia rossi is the cause of a highly virulent multisystemic disease with a variable outcome, which is a reliable model of systemic inflammatory response syndrome (SIRS). The objective of this study was to determine the concentration of canine pancreatic-specific lipase (cPL) in a population of dogs with naturally acquired B. rossi infection. In addition, the associations between serum cPL and...

OBJECTIVE To determine whether the development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) associated with systemic inflammatory response syndrome (SIRS) can be predicted by the plasma neutrophil elastase level. PATIENTS AND METHODS Patients were sequentially enrolled after obtaining informed consent. Twenty-three adult patients with SIRS were classified into the...

BACKGROUND Many human infectious diseases are caused by pathogens that have multiple strains and show oscillation in infection incidence and alternation of dominant strains which together are referred to as epidemic cycling. Understanding the underlying mechanisms of epidemic cycling is essential for forecasting outbreaks of epidemics and therefore important for public health planning. Current ...

PURPOSE Due to the seroepidemiological shift in hepatitis A (HA), its severity, mortality, and complications have increased in recent years. Thus, the aim of this study was to identify predictive factors associated with poor prognosis among patients with HA. MATERIALS AND METHODS A total of 304 patients with HA admitted to our institution between July 2009 and June 2011 were enrolled consecut...

Systemic inflammatory response syndrome (SIRS) is a common clinical condition in patients in intensive care units that can lead to complications, including multiple organ dysfunction syndrome (MODS). MODS carries a high mortality rate, and it is unclear why some patients resolve SIRS, whereas others develop MODS. Although oxidant stress has been implicated in the development of MODS, several re...