نتایج جستجو برای: epidemiology of retinoblastoma
تعداد نتایج: 21170815 فیلتر نتایج به سال:
BACKGROUND Ophthalmic artery chemosurgery [OAC, intra-arterial chemotherapy (IAC)] was introduced in 2006 as treatment modality for intraocular retinoblastoma. The purpose of this commentary is to retrospectively review the incidence of metastatic deaths in retinoblastoma patients treated with OAC worldwide over a 10 year period. Retrospective data regarding metastatic deaths was collected from...
October 2005 | Volume 2 | Issue 10 | e332 Retinoblastoma is a rare childhood cancer of the retina. Approximately one in 20,000 children are affected worldwide; only 250 to 300 new cases are reported in the United States each year. Enucleation (see Glossary) is usually the treatment of choice for children with unilateral disease. Treatment of children with bilateral retinoblastoma is more challe...
We created a rabbit model of retinoblastoma and confirmed the tumor clinically and histopathologically. Seventeen New Zealand rabbits were immunosuppressed with cyclosporin A at doses of 10-15 mg/kg. At day 3, the animals received a 30 μl subretinal injection of 1 x 10⁶ cultured WERI retinoblastoma cells. Digital fundus images were captured before euthanasia, and the eyes were submitted for his...
Human embryonic stem cells (hESCs) provide a platform for studying human development and understanding mechanisms underlying diseases. Retinoblastoma-1 (RB1) is a key regulator of cell cycling, of which biallelic inactivation initiates retinoblastoma, the most common congenital intraocular malignancy. We developed a model to study the role of RB1 in early development and tumor formation by gene...
classification. Ophthalmol Clin North Am. 2005;18(1):41-53, viii. 3. Chan HSL, Grogan TM, DeBoer G, Haddad G, Gallie BL, Ling V. Diagnosis and reversal of multidrug resistance in paediatric cancers. Eur J Cancer. 1996; 32A(6):1051-1061. 4. Gallie BL, Budning A, DeBoer G, et al. Chemotherapy with focal therapy can cure intraocular retinoblastoma without radiotherapy. Arch Ophthalmol. 1996; 114(1...
Background and Aim: Although combined "Chemotherapy and Focal therapy" is very efficient in the treatment of the low grade forms of Retinoblastoma (Rb), more effective therapeutic measures are required to control the spread of the disease into vitreous and subretinal areas.This study was conducted with the aim of evaluating the effectiveness of chemotherapy combined with perioricular inject...
Retinoblastoma is the most common primary intraocular tumour of childhood. Though congenital, it is not diagnosed at birth, and is usually seen between 1-2 years of age. We here report a case of bilateral retinoblastoma with early presentation at the age of one month.
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