Recent US Food and Drug Administration approval of new antiepileptic drugs (AEDs) offers a significant improvement in the treatment of childhood epilepsy. After a period of many years, during which no new AEDs became available, 7 new AEDs were introduced in the United States beginning in 1993. Approximately 25% of pediatric patients who remain refractory to therapy with conventional epileptic d...

Although spontaneous and simultaneous bilateral hip fractures without trauma are seen rarely, epileptic seizures may lead to these fractures. We present an 82-year-old female patient with poor bone quality and a 20-year history of epilepsy. She had been using anticonvulsant drugs for almost 20 years. Following a convulsive epileptic attack, bilateral intertrochanteric femur fractures occurred (...

INTRODUCTION AND OBJECTIVE The hyperplasia of synovial fibroblasts is considered to be essential for the evolution of joint destruction in rheumatoid arthritis (RA). Previously, we reported that anti-rheumatic drugs, both COX inhibitors and disease-modifying anti-rheumatic drugs inhibit proliferation of synoviocytes in vitro. The presented study investigates the effect of anti-epileptic drugs o...

The book describes recent advances in diagnostic radiology which are improving discrimination in difficult cases and advancing understanding of the disease. Each of the different groups of medical therapies is appointed a chapter. What seemed (to this medical SHO) a mildly bewildering array of pharmaceuticals for the treatment of this disease is reduced to four groups with clear indications and...

Despite an abundance of information on clinical and experimental epilepsy and on the drugs effective in its treatment, we 3rc still without a full undentanding of the inherent etiology of the epileptogenic focus and the mechanism of action of anticonvulsant drugs. In recent years allcolion has therefore been mainly directed towards the elucidation of these factors on a neuropharmacological and ...

PURPOSE In epileptic patients fractures are six times more frequent than in the general population. Known predisposing factors are anticonvulsant drugs, malnutrition, lack of physical activity and sunlight exposure. METHODS In this study we describe two patients, one with a bilateral supracondylar fracture and one with a unilateral supracondylar fracture after an epileptic seizure. The litera...

When unrestrained cats were with ketamine 2-6 mg kg-1 i.v., anaesthesia was associated with seizure waves induced in the cortical e.e.g. After cats were pretreated with trimethadione 500 mg kg-1 i.p., ketamine did not induce seizure waves. Pretreatment with diphenylhydantoin 25 or 100 mg kg-1 i.p. slightly enhanced seizure waves following ketamine. In both situations the anaesthetic effect of k...

Epilepsy is three to six times more frequent in multiple sclerosis than in the general adult population. The probable anatomic basis for the seizures is areas of inflammation and demyelination in the cortex and juxtacortical white matter. Partial epilepsies with focal seizures often with atypical symptoms and with or without secondary generalisation are the usual pattern. Seizures can be observ...

Epilepsy is a common chronic neurological disorder that requires long-term or sometimes lifetime therapy. Recent evidence indicates that prolonged use of antiepileptic drugs (AEDs) might modify some vascular risk factors; however, the influence of AED therapy on the development of atherosclerosis has been the subject of controversy. Some epidemiological studies have reported a higher prevalence...