Slipping of the upper femoral epiphysis has been recognised since 1572 when it was first described by Pare, but its cause has not yet been fully determined. Treatment has been a controversial subject since the late nineteenth century when operative measures were first practised. The pendulum for and against operation has been swinging ever since, with a bias towards conservative treatment. The ...

background: appropriate endurance exercise can change bone mass density and strength of weight-bearing bones in both animals and humans, but its effects on the microstructure are not known. this study aimed to determine skeletal changes induced by the treadmill running endurance in ovariectomized adult mice. methods: twenty-seven adult female rats were divided into experimental and control grou...

PURPOSE To describe and comment on the treatment of the slipped capital femoral epiphysis (SCFE) with pinning and to present the pros and cons of prophylactic pinning of the contralateral hip. SUMMARY Pinning the SCFE aims to fix the epiphysis and prevent further slipping. Some devices allow for further growth and remodeling of the femoral neck post-operatively. This results in maintained fem...

Long bones develop from cartilage by a process of endochondral (within cartilage) ossification (Fig 1). In the fetus, the bone anlages (early bone templates) are composed entirely of cartilage. Centers of ossification (bone formation) develop in the center of the future long bone (diaphysis) and also at the ends of these long bones (epiphysis). As ossification proceeds, a bony epiphysis develop...

The epiphysial region of the dorsal diencephalon is the first site at which neurogenesis occurs in the roof of the zebrafish forebrain. We show that the homeobox containing gene floating head (flh) is required for neurogenesis to proceed in the epiphysis. In flh- embryos, the first few epiphysial neurons are generated, but beyond the 18 somite stage, neuronal production ceases. In contrast, in ...

Few observations have been made on the histological changes associated with slipped femoral epiphysis. Those that are available are confusing, if not actually misleading, in that they have been made on material removed at operation some considerable time after the event, and thus show only the late stages of repair (Lacroix and Verbrugge 1951, Sutro 1935). SO far as we are aware no observations...

Dysplasia epiphysealis hemimelica, also known as Trevor's disease, is a rare developmental disorder with osteocartilagenous overgrowth of the epiphysis or epiphyseal equivalent. The condition bears similarities to osteochondroma in terms of its radiographic appearance, but differs in its pathobiology and geographic occurrence. Unlike the metaphyseal occurrence of osteochondromata, it arises fro...

Varus deformity at the upper end of the tibia was reported by Erlacher (1922) and LUlsdorf (1931), who considered it to be a type of osteochondritis. Blount (1937) presented a personal series of thirt en cases and reviewed fifteen cases from the literature. He called the condition tibia vara and suggested that the term osteochondrosis was more appropriate than osteochondritis. Further reports o...

The exact cause of slipped capita! femora! epiphysis remains unclear. Hormonal imbalance has been suggested but has not been substantiated by a recent study (Brenkel et a! 1989). A strong familial incidence has been well documented by Rennie (1982), who suggested an autosoma! dominant pattern of inheritance with variable penetrance. To date only two cases have been described in identical twins ...