NACHEVA, I., K. ALEKSIEVA, K. DIMOV, D. MITEVA and Tsv. TSVETKOV, 2013. Identification of gamma irradiated lyophilized forest fruits by EPR Spectroscopy. Bulg. J. Agric. Sci., 19: 293-297 The objective of the present study was to prove the radiation treatment of a set of lyophilized forest fruits (blackberry, blueberry, aronia, strawberry and black elder), irradiated with doses of 2 and 4 kGy b...

We report on the tetraruthenium macrocycles Ru4-5 and -6 with a π-conjugated pyrene-appended 5,8-divinylquinoxaline ligand either isophthalate or thiophenyl-2,5-dicarboxylate linkers their charge-transfer salts formed by oxidation two equivalents of F4TCNQ. Both macrocyclic complexes were characterized NMR spectroscopy, mass spectrometry, cyclic square-wave voltammetry, IR, UV–vis–NIR, EPR spec...

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Three new hydrazide and five new hydrazonoyl derivatives were synthesized. The chemical structures of these compounds were confirmed by 1H-NMR, IR spectroscopy and elemental analysis. The prepared compounds were tested for their activity to inhibit photosynthetic electron transport in spinach chloroplasts and growth of the green algae Chlorella vulgaris. IC50 values of these compounds varied in...

Objective(s): Nanocarriers are drug delivery vehicles, which have attracted the attention of researchers in recent years, particularly in cancer treatment. The encapsulation of anticancer drugs using protein nanocages is considered to be an optimal approach to reducing drug side-effects and increasing the bioavailability of anticancer drugs. Epirubicin (EPR) is an active chemotherapeutic medica...

Gamma (gamma)-irradiation is finding increasing use in the sterilization of pharmaceutical products. However, irradiation also might affect the performance of drug delivery systems. In this study, the influence of gamma-irradiation on the characteristics of chitosan microparticles was investigated. The diclofenac sodium was incorporated into chitosan microparticles by spray-drying method. The c...

Introduction. Amyotrophic lateral sclerosis (ALS) is a progressive and fatal motor neuron disease characterized by selective degeneration of motor neurons in the brain stem, spinal cord, and motor cortex. Approximately 5–10% of ALS cases are familial, and 15–20% of these are linked to a mutation in Cu/Zn superoxide dismutase (SOD1) gene. Mice expressing mutant G93A-SOD1 (glycine to alanine subs...

Denaturant-perturbation and pulsed EPR spectroscopy are combined to probe the folding of the membrane-bound Na,K-ATPase active transport system. The Na,K-ATPase enzymes from shark salt gland and pig kidney are covalently spin labelled on cysteine residues that either do not perturb or are essential to hydrolytic activity (Class I and Class II -SH groups, respectively). Urea increases the access...

Several reports in the literature have described the effects of radiation in workers who exposed their fingers to intense radioactive sources. The radiation injuries occurring after local exposure to a high dose (20 to 100 Gy) could lead to the need for amputation. Follow-up of victims needs to be more rational with a precise knowledge of the irradiated area that risks tissue degradation and ne...

Alamethicin, a hydrophobic peptide that is considered a paradigm for membrane channel formation, was uniformly labeled with 15N, reconstituted into oriented phosphatidylcholine bilayers at concentrations of 1 or 5 mol %, and investigated by solid-state NMR spectroscopy as a function of temperature. Whereas the peptide adopts a transmembrane alignment in POPC bilayers at all temperatures investi...