PURPOSE To examine photoreceptor function in diabetes in detail by evaluating photoreceptor light activation, deactivation of the photoresponse, and recovery of the photoreceptor after bleaching (dark adaptation) in rats made diabetic with streptozotocin (STZ). METHODS Animals were assigned to treated and control groups. Light activation in rod photoreceptors was established using a paired-fl...

A series of twelve platinum(II) complexes of the form (N^N^N)PtX have been synthesized and characterized where N^N^N is 1,3-bis(2-pyridylimino)isoindolate ligands (BPI) or BPI ligands whose aryl moieties are substituted with tert-butyl, nitro, alkoxy, iodo or chloro groups, and X is a chloride, fluoride, cyano, acetate, phenyl or 4-(dimethylamino)phenyl ligand. All complexes display at least on...

We constructed a predictive model of the total deactivation rate constant (k(t)) of singlet oxygen by heterocyclic compounds that are widespread in biological systems and participate in highly relevant biologic functions related with photochemical processes, by means of quantitative structure-property relationships (QSPR). The study of the reactivity of singlet oxygen with biomolecules provides...

1. To determine their contributions to the rapid kinetic properties of GABAA receptor (GABAR) currents, alpha1 and beta3 subunit subtypes without or with delta or gamma2L subtypes were transiently coexpressed in mouse L929 fibroblasts to produce alpha1beta3, alpha1beta3delta, or alpha1beta3gamma2L GABAR isoforms. 2. Brief (2-3 ms) applications of 1 mM GABA to outside-out membrane patches contai...

ThermoCatalytic Decomposition of methane (TCD) is studied as a method to convert natural gas into hydrogen and functional carbon. In these processes the carbon typically formed on top catalyst phase leading particle growth. Therefore, development growth model necessary understand limitations thermocatalytic decomposition assess optimal parameters process conditions. this paper, presented descri...

Reduced task deactivation within regions of the default mode network (DMN) has been frequently reported in Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). As task deactivation reductions become increasingly used in the study of early AD states, it is important to understand their relationship to atrophy. To address this issue, the present study compared task deactivation...