Solubility and permeability are key parameters for establishing in vitro-in vivo correlation poorly water-soluble active pharmaceutical ingredients (APIs). Recent studies demonstrate that not only solubility, but also effective of the API may change due to addition solubilizing agents, there is a certain mathematical relation between these physicochemical parameters. The aim this study was show...

The oral route is the preferred option for drug administration but contains the inherent issue of drug absorption from the gastro-intestinal tract (GIT) in order to elicit systemic activity. A prerequisite for absorption is drug dissolution, which is dependent upon drug solubility in the variable milieu of GIT fluid, with poorly soluble drugs presenting a formulation and biopharmaceutical chall...

Struvite is known to form a hard scale in specific areas of wastewater treatment plants. Besides causing problems; struvite can also be used as a fertilizer. Good and reliable solubility data is essential for controlling the crystallisation of struvite. One of the important factors that affect the crystallisation of struvite is solution pH. Therefore, this study was undertaken to investigate in...

The colloidal stability, phase behavior, and solubility of silica nanoparticles (3-10 nm) that are formed in basic solutions of monovalent cations (primarily tetrapropylammonium) are investigated using a combination of chemical equilibria and electrostatic models. The free-energy gain associated with the formation of an electric double layer surrounding the nanoparticle was obtained by solving ...

Since the introduction of gliclazide in the pharmaceutical industry, a large number of research groups have been engaged in various investigations aiming to enhance its biomedical application. But, very limited efforts have been made to study polymorphism of gliclazide. Therefore, this study focuses on solvent-induced polymorphism of gliclazide and its characterization by thermal methods. Three...

The effects of 22 lyotropic salts on the polymerization of deoxygenated sickle hemoglobin (deoxy-Hb S) were evaluated. The equilibrium solubility was measured as the saturation concentration, cBat, after phase separation by centrifugation at 30°C. The linear plots of csat uersus salt concentration allowed the assignment of particular cations or anions as either salting-in (csat increased) or sa...

An experimentally practical and precise flocculation-based method was developed, tested, and applied to determine phenanthrene and 1,2,4-trichlorobenzene sorption with NIST SRM 2975 diesel particulate matter. Following an initial equilibration period, polyaluminum chloride (PACI) solution was added to the sorption tubes in order to facilitate the formation of flocculated aggregates of soot part...

The interaction between the potent anticancer agent 2-methoxyestradiol (2ME) and a series of cyclodextrins (CDs) was investigated in the solid state using thermal analysis and X-ray diffraction, while the possibility of enhancing its poor aqueous solubility with CDs was probed by means of equilibrium solubility and dissolution rate measurements. Single crystal X-ray diffraction studies of the i...

The possibility and usefulness of sinple liquid models is reported. The importance of van der Waals forces for liquid water and aqueous solutions is discussed and compared with the solubility of water in nonpolar solvents and as well as of nonpolar solvents in water. Both systems could be understood as equilibrium of few water monomers. The network of H-bonded water molecules seems to be less i...

The understanding of the specific interactions between salt ions and ionic liquids (ILs) in aqueous solutions is relevant in multiple applications. The influence of a series of anions on the solubility of 1-butyl-3-methylimidazolium tricyanomethane in aqueous environment was here studied. This study aims at gathering further information to evaluate the recently proposed mechanisms of salting-in...