in order to ensure the safety of parenterals, international pharmacopoeias and national standards have set up stringent guidelines and standards. particulate con- tamination is a potential health risk caused by intravenous injection of particles large enough to potentially clog the small arteries. particles could be produced through manufacturing and packaging or even dispensing of the pharmace...

Chemical contamination and disease outbreaks have increased in many ecosystems. However, connecting pollution to disease spread remains difficult, in part, because contaminants can simultaneously exert direct and multi-generational effects on several host and parasite traits. To address these challenges, we parametrized a model using a zooplankton-fungus-copper system. In individual-level assay...

Introduction The in situ method is used widely to determine ruminal degradability of feed CP and DM. It is an attractive alternative to in vivo methods because it is simple, inexpensive, and rapid. However, several factors influence in situ results, the most important of which is microbial contamination of feed residues after incubation in the rumen. Degradation of forage CP and DM is systemati...

One of the main problems in cell culture is mycoplasma infection. It can extensively affect cell physiology and metabolism. As the applications of cell culture increase in research, industrial production and cell therapy, more concerns about mycoplasma contamination and detection will arise. This review will provide valuable information about: 1. the ways in which cells are contaminated and the...

DNA sample contamination is a serious problem in DNA sequencing studies, and may result in systematic genotype misclassification and false positive associations. While methods exist to detect and filter out cross-species contamination, few methods to detect within-species sample contamination are available. In this paper, we describe methods to identify withinspecies DNA sample contamination ba...

BACKGROUND The purpose of this study was to examine the difference in self-contamination rates and levels of contact and droplet protection associated with enhanced respiratory and contact precautions (E-RCP) and a personal protective system that included a full body suit, personal protective equipment and a powered air-purifying respirator (PAPR). METHODS In this prospective, randomized, con...

Contamination of the external surface of anticancer drug vials supplied to hospital pharmacies has been recognized as a potential health hazard. The aim of this study was to investigate the levels of contamination on the exterior surface of vials containing platinum anticancer drugs in Japan. Platinum contamination on the exterior surface of vials containing cisplatin or carboplatin was examine...

The standard index of microbial air contamination (IMA) for the measurement of microbial air contamination in environments at risk is described. The method quantifies the microbial flow directly related to the contamination of surfaces coming from microbes that reach critical points by falling on to them. The index of microbial air contamination is based on the count of the microbial fallout on...

This paper investigates one aspect of the robustness of Fisher's linear discriminant function-robustness against contamination in the initial samples. Asymptotic results are derived for normal location contamination and for normal scale contamination with the contaminating covariance matrix a multiple of the uncontaminated population covariance matrix. It is shown that when the prior probabilit...