We report the rational design, based on docking simulations, and synthesis of the first fluorescent and selective probe of GPER for bioimaging purposes and functional dissecting studies. It has been conceived as a Bodipy derivative and obtained by accessible and direct synthesis. Its optical properties have been measured in different solvents, showing insensitivity to their polarity. Its bindin...

New results from the CCFR Collaboration on the structure functions F2 and xF3 are presented. Neutrino scattering structure function measurements o er a unique tool to probe the strong interactions. The parity-violating structure function xF3(x;Q ) can only be measured in deep inelastic neutrino scattering. Precise measurements of the structure function F2(x;Q ) can also be obtained. The predict...

We investigate the dynamical alignment of jet-cooled OCS molecules induced by a short laser pulse. The alignment is measured through the orientational contribution of the optical Kerr effect using a second weak laser pulse as a probe. Maximum alignment is observed at conditions close to saturation of ionization. The results are analysed with a quantum mechanical model solving for the rotational...

Nanosized precipitates in an Al–0.06Sc at.% alloy containing various microalloying additions were studied, with the goal of developing cost-effective aluminum alloys for high-temperature applications, using micro-hardness, electrical conductivity and atom-probe tomography measurements. Substituting 0.005 at.% Er for the more expensive Sc maintains high ambient-temperature strength, and dramatic...

Abstract. Paper reports observation of the LH transition at very low density in the experiments on countercurrent Neutral Beam Injection (NBI) in the TUMAN-3M tokamak. The transition has been found at target average density as low as 0.5⋅10 m. Low input power in these experiments should be noticed: Pinput ≈ 1.3POHM < 240 kW. Contrary, in the case of co-current NBI the LH transition is difficult...

Activation of intracellular transient receptor potential vanilloid-1 (TRPV1) in human lung cells causes endoplasmic reticulum (ER) stress, increased expression of proapoptotic GADD153 (growth arrest- and DNA damage-inducible transcript 3), and cytotoxicity. However, in cells with low TRPV1 expression, cell death is not inhibited by TRPV1 antagonists, despite preventing GADD153 induction. In thi...

Objective Background: Failure in the endometrial receptivity may account for a significant number of infertility cases including unexplained infertility in women. Reduction in the endometrial estrogen receptor-alpha (ER-α) expression during window of implantation may be a critical event that coincides with expression of specific genes and providing a receptive endometrium. The aim of present st...

In eukaryotic cells, polypeptides are N glycosylated after passing through the membrane of the ER into the ER lumen. This modification is effected cotranslationally by the multimeric oligosaccharyltransferase (OST) enzyme. Here, we report the first cross-linking of an OST subunit to a nascent chain that is undergoing translocation through, or integration into, the ER membrane. A photoreactive p...

0191-8869/$ see front matter 2011 Elsevier Ltd. A doi:10.1016/j.paid.2011.08.030 ⇑ Corresponding author. Address: Department o Calgary, 2500 University Dr., N.W. Calgary, AB, Canad 4667; fax: +1 403 282 8249. E-mail address: [email protected] (J.E. Arndt). Emotion regulation (ER) strategies differ in when and how they influence emotion experience, expression, and concomitant cognition. Howeve...