Bone destruction is the most difficult target in the treatment of rheumatoid arthritis (RA). Here, we report that local overexpression of IL-4, introduced by a recombinant human type 5 adenovirus vector (Ad5E1mIL-4) prevents joint damage and bone erosion in the knees of mice with collagen arthritis (CIA). No difference was noted in the course of CIA in the injected knee joints between Ad5E1mIL-...

This in vitro study evaluated the compositional, crystalline, and morphological effects promoted by Nd:YAG laser on root dentin, and verified the effects of laser and topical acidulated phosphate fluoride application (APF-gel) on dentin erosion. 180 bovine dentin slabs were randomized into 4 groups (n = 45): G1-untreated, G2-APF-gel (1.23% F-, 4 min), G3-Nd:YAG (1064 nm, 84.9 J/cm², 10 Hz), and...

Studies have been conducted to find Materials with microstructures which Minimize the formation of blisters. A promising class of materials appears to be sintered metal powder with small average grain sizes and low atomic number Z. Studies of the surface erosion of sintered aluminum powder (SAP 895) and of aluminum held at AOO'C due to blistering by 100 keV helium ions have been conducted and t...

Aeolian process and subsequently soil erosion are key factors in dryland environments. Such phenomena are related not only to geoecological factors (lithology, topography, and climatology) but also to land-use and plant cover changes. Formation of new sand dunes in Damghan explains the development of human activities over the past. The aim of this study is to explain the land use changes and th...

The Late Cretaceous to Early Tertiary subsidence history of the Northern Calcareous Alps (NCA) records the effect of two independent basin formation mechanisms at the northern leading margin of the Austroalpine unit. The terrestrial to shallow-marine sediments of the Lower Gosau Subgroup were deposited mainly within small, fault-bound basins during a phase of strike-slip faulting from the late ...

We present a new real-time hydraulic erosion simulation for Computer Graphics. In our system water runs over the surface and disintegrates the underlying layer of soil. The grit is simulated as a fluid with higher viscosity and moves on the ground of the water pool. When water evaporates, or the dissolved soil exceeds a critical level, the dissolved matter is deposited back on the ground for ac...

Dental erosion develops through chronic exposure to extrinsic/intrinsic acids with a low pH. Enamel erosion is characterized by a centripetal dissolution leaving a small demineralized zone behind. In contrast, erosive demineralization in dentin is more complex as the acid-induced mineral dissolution leads to the exposure of collagenous organic matrix, which hampers ion diffusion and, thus, redu...

Low Earth orbital debris impacts on the external surfaces of satellites have increased dramatically in recent years. Polyimides are used as the outer layer of thermal control insulation blankets, covering most of the external spacecraft surfaces that are exposed to the space environment. A recently developed material, named polyhedral oligomeric silsesquioxane (POSS)-polyimide, shows significan...

This field trip provides an opportunity to reevaluate the processes responsible for some subglacial bedrock erosion features in northern Ohio. Beginning in the 1830s, quarrying operations on Kelleys Island, OH, have uncovered several giant grooves on the bedrock surface. One such groove remains for investigation today. There is agreement that these features were formed mainly in a subglacial en...