OBJECTIVES Cytomegalovirus (CMV) infection has an enormous impact in solid-organ transplant patients. In immunocompromised patients, CMV is associated with well-known direct effects. We herein describe 3 unusual patterns occurring in the setting of tissue-invasive CMV associated with high viral load. MATERIALS AND METHODS Of our 3 cases, the first patient after kidney transplant presented wit...

Sarcoidosis is a granulomatous disease that can involve multiple organs including the lungs, eyes, nerves, and skin. Cosmetic tattooing can be a predisposing factor for sarcoidosis, and its incidence is likely to increase along with its popularity. A 47-year-old woman with symptoms of fever and polyarthritis along with erythema nodosum lesions on the legs, swollen eyebrows, and a history of mul...

Leprosy is a chronic disease caused by Mycobacterium leprae. Its course is complicated by acute onset of inflammatory reactions which can occur before, during and after treatment of the disease. The reactions are classified as Type 1 reaction or reversal reaction and Type 2 reaction or erythema nodosum leprosum (ENL). Reversal reaction is a Type IV delayed type hypersensitivity reaction while e...

Epstein-Barr virus (EBV) is one of the eight known human herpesviruses, which widespread in nature and infects most world population. In infants young children, primary infection usually asymptomatic or produces an acute illness that often not recognized as being due to EBV. It has a well-established oncogenic potential, been implicated pathogenesis various autoimmune diseases. Here reported ca...

Patient Concerns: A 58-year-old Chinese female was admitted for a 4-week history of painful cutaneous lesions, accompanied by a sternal pain and fever. The lesions once resolved spontaneously but then recurred. Physical examination revealed warm, tender, indurated, rounded, erythematous to violaceous nodules in bilateral lower extremities, ranging in diameter from 1 to 6cm. Blood marrow examina...

BACKGROUND Idiopathic granulomatous mastitis (IGM) is an uncommon benign chronic inflammatory breast disease, and erythema nodosum (EN) is an extremely rare systemic manifestation of IGM. Here, we report a rare case of IGM accompanied by EN. CASE REPORT A 32-year-old patient was admitted to our clinic with a history of a tender mass in the right breast. On physical examination, the right brea...

Cutaneous lesions are frequent in medium-sized and small vessel systemic vasculitides. The classic cutaneous manifestation of vasculitis is palpable purpura; however the clinical manifestations greatly depend on the size of the vessels affected. They usually do not affect prognosis but relapsing or intractable forms have been described. When skin manifestations are only one of the clinical sign...

Before 1983 physicians diagnosed cat-scratch disease by its clinical manifestations and a positive Hanger-Rose skin test. Three out of four criteria, as outlined by Warwick, 1 were required for diagnosis. In 1983 Wear, et al.2 reported that they found gram-negative pleomorphic organisms using the Warthin-Starry stain on lymph nodes from patients with cat-scratch disease. The organism was then i...