Background & Aims: Esophageal and gastric cancers are among prevalent cancers in the world and it is believed that nitrate and nitrite contaminations of drinking water are important factors in increasing the risk of these cancers. This study was designed to determine the correlations between these factors and upper gastrointestinal cancers. Methods: In this ecologic study, mean concentrations o...

Esophageal ulcers are a rare cause of upper gastrointestinal bleeding. This report describes the etiology, treatment, complications, and outcome of esophageal ulcers. An esophageal ulcer is defined as a discrete break in the esophageal mucosa with a clearly circumscribed margin; esophageal ulcers were seen in 88 patients from a total of 7564 esophagogastroduodenoscopies done by one surgeon at a...

two new potential magnetic resonance imaging contrast agents, gd-hematoporphyrin (gd-h) and gd-tetra-carboranylmethoxyphenyl-porphyrin (gd tcp), were synthesized and applied to nude mice with human melanoma (mm 138) xenografts. these agents showed a high relaxivity because of their greater potential to coordinate water molecules. the reduction of t1 relaxation times of 16 and 21% was observed i...

primary oral melanoma is a rare neoplasm of melanocytic origin, accounting for 0.5% of all oral malignancies. the “chameleonic” presentation of a mainly asymptomatic condition, rarity of this lesion, poor prognosis, and the necessity of a highly specialized treatment are factors that should be seriously considered by the involved health provider. here is a case report presenting a malignant mel...

Background: Hydatid cyst is the larval stage of the tape worm parasite, Echinococcus granulosus. Human is infected by ingestion of parasite ova excreted in dog feces. The anticancer activity of different antigens of hydatid cyst has been reported in the previous works. In this research, the role of immune system in induction of this anticancer activity has been investigated.Materials and Method...

Dear Editor-in-ChiefMalignant melanoma is a tumor arising from melanocyte; this tumor rarely occurs before puberty, with higher mortality rate in males and better survival rate in female patients affected by metastatic melanoma (1, 2). These facts propose that a relationship and association may exist between estrogens and melanoma. The effects of estrogens are mediated by...

background: esophageal carcinoma is one of the most lethal gastrointestinal (gi) malignant tumors worldwide.  the disease is known to have a high incidence in northern iran; however, its condition in the south is not much clear.   objective: in this retrospective study we investigated the epidemiology and time trends of esophageal carcinoma in fars province, south of iran.   methods : in a retr...

background dietary factors such as intake of minerals may play a role in the etiology of esophageal cancer. although it has been hypothesized that manganese can affect the risk of some types ofcancer, its role in esophageal cancer is unknown. the objective of this study was to investigate the association between intakes of manganese with esophageal cancer in golestan cohort study. materials and...