The patient was having a minor procedure undertaken under general anaesthetic and was self-ventilating via a laryngeal mask. Constant gas flows and volatile agent concentration were used and the patient’s minute ventilation remained constant. However, ETCO2 values, as measured by Hewlett Packard M1026A gas analyser (Hewlett Packard, Berkshire, UK), varied between 22 and 43 mmHg. Initially no ca...

Abstract Introduction The constellations of symptoms known as obstructive sleep apnea (OSA) results from either partial or complete airway obstruction during sleep. This affects effective gas exchange and disrupts architecture resulting in fragmentation with downstream immediate long-term adverse effects. Obesity is a significant risk factor childhood OSA, especially post-pubertal children. Obe...

Abstract Background Three AD Centers have joined together to study the regulation of cerebral perfusion at resting conditions using spontaneous time‐series data with a modeling methodology that previously yielded indications reduced dynamic vasomotor CO2 reactivity in amnestic MCI patients [ Marmarelis et al., J. Alzh. Dis. 56:89–105, 2017 ] and significant correlation this reduction functional...

OBJECTIVE: The role of supraglottic airway devices in emergency airway management is highlighted in international airway management guidelines. We evaluated the application of the new generation laryngeal tube suction (LTS-II/LTS-D) in the management of in-hospital unexpected difficult airway and cardiopulmonary resuscitation. METHODS: During a seven-year period, patients treated with a laryn...

BACKGROUND The objective was to determine the repeatability and stability of capnography interfaced with human exposure facility. METHODS Capnographic wave signals were obtained from five healthy volunteers exposed to particle-free, filtered air during two consecutive 5 min intervals, 10 min apart, within the open and then the sealed and operational human exposure facility (HEF). Using a cust...

The association between neural activity and cerebral blood flow (CBF) has been used to assess neurovascular coupling (NVC) in health and diseases states, but little attention has been given to the contribution of simultaneous changes in peripheral covariates. We used an innovative approach to assess the contributions of arterial blood pressure (BP), PaCO2, and the stimulus itself to changes in ...

BACKGROUND Many infants born at less than 34 weeks of gestational age will require resuscitation in the delivery suite. Yet, different resuscitation techniques are specified in different national guidelines, likely reflecting a limited evidence base. One difference is the length of mechanical inflation initially delivered to infants either via a facemask or endotracheal tube. Some guidelines sp...

Obstructive sleep apnoea (OSA) patients on opioid analgesic have an increased incidence of postoperative respiratory complications; prevention of these may be possible with appropriate post-operative monitoring. We recruited 4 OSA patients who had general anaesthesia for orthopaedic and septoplasty surgery. They required Patient Controlled Analgesia (PCA) or oral opioids in the post-operative p...

BACKGROUND Computed tomography (CT) phenotypic characterization helps in understanding the clinical diversity of chronic obstructive pulmonary disease (COPD) patients, but its clinical relevance and its relationship with functional features are not clarified. Volumetric capnography (VC) uses the principle of gas washout and analyzes the pattern of CO2 elimination as a function of expired volume...