BACKGROUND Chlorpromazine (CPZ), a commonly used antipsychotic drug, was found to play a neuroprotective role in various models of toxicity. However, whether CPZ has the potential to affect brain apoptosis in vivo is still unknown. The purpose of this study was to investigate the potential effect of CPZ on the apoptosis induced by exogenous stimuli. METHODOLOGY The ethanol treated infant rat ...

Essential tremor (ET) is one of the most common and most disabling movement disorders among adults. The drug treatment of ET remains unsatisfactory. Additional therapies are required for patients with inadequate response or intolerable side effects. The current study aims to investigate the anti-tremogenic and neuroprotective effects of memantine (NMDA receptor antagonist) on the harmaline mode...

DARPP-32 (dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein, 32 kDa) is an important component of dopaminergic function in brain areas thought to be important for drug and alcohol addiction. The present experiments characterized the acquisition of ethanol-induced conditioned taste aversion, ethanol-induced conditioned place preference, and ethanol self-administration in DARPP-...

Experiments were conducted to evaluate the performance of a low heat rejection (LHR) diesel engine. Performance parameters and emission levels were determined at various magnitudes of brake mean effective pressure. Combustion characteristics of the engine were measured with TDC (top dead centre) encoder, pressure transducer, console and special pressure-crank angle software package at peak load...

The aversive properties of alcohol can be examined by using ethanol as a conditioning agent in a taste aversion (TA) paradigm. However, there is often variability in how organisms respond to the aversive properties of alcohol. Using a selectively bred line of TA-prone (TAP) rats, the present study sought to determine if antagonizing the GABA receptor complex with picrotoxin could block the acqu...

Aim. To investigate whether differences in the amounts of effective index components in Jakyak-Gamcho decoctions derived via extraction with either water or ethanol were associated with differential spasmolytic effectiveness. Methods. The amounts of effective index components (paeoniflorin, benzoic acid, glycyrrhizin, and isoliquiritin) contained in water-extracted Jakyak-Gamcho decoction and 7...

A flow injection method was developed for the sequential enzymatic determination of ethanol and glycerol in wines, using immobilised ethanol dehydrogenase and glycerol dehydrogenase, respectively. The enzymes were immobilised separately on alkylaminated controlled pore glass. A multi-site spectrophotometric detection system was used in parallel configuration to monitor the absorbance change in ...

Emergency endoscopy, carried out in 342 cases of UGI overt bleeding at the Third Department of Internal Medicine, Tohoku University during the six year period from June 1979, demonstrated the necessity of endoscopic hemostasis in 171 cases (50%) with active bleeding, adhered fresh blood clot or exposed vessel with bloody gastric juice. The absolute ethanol injection method was applied to achiev...

The increasing prevalence of binge drinking and its association with trauma necessitate accurate animal models to examine the impact of intoxication on the response and outcome to injuries such as burn. While much research has focused on the effect of alcohol dose and duration on the subsequent inflammatory parameters following burn, little evidence exists on the effect of the route of alcohol ...

Mouse oocytes were collected 13.5-29.5 hr after hCG injection at 4 hr intervals, then activated with 7% ethanol for 1 min. The oocytes collected 13.5 hr after hCG injection did not respond to ethanol activation. High activation rates (90.2-98.3%) were obtained in oocytes activated 17.5-29.5 hr after injection with hCG. Haploid parthenogenones were dominant though the number decreased as the age...