PURPOSE The aim of the study was to obtain pharmacokinetic data for carbamazepine (CBZ) and its fractions not bound with proteins in bitherapy with lamotrigine (LTG), topiramate (TPM), vigabatrin (VGB) or valproic acid (VPA) in children and adolescents treated for epilepsy. MATERIAL AND METHODS The participants of the presented investigations were fifty-five patients with epilepsy who were un...

in industries, preventive maintenance (pm) is not a new practice to minimise the sudden breakdown of production machine. pm will be performed at predetermine intervals to provide a balance between failure cost and component utilisation (aging). however, most of pm interval is based on experience or original equipment manufacturer (oem) recommendations. consequently, the benefits from pm are not...

The anticonvulsant effects produced by topiramate (TPM) and gabapentin (GBP)--two second-generation antiepileptic drugs, in numerous fixed-ratio combinations of 8:1, 4:1, 2:1, 1:1, 1:2, 1:4 and 1:8 were examined by isobolographic analysis in the mouse maximal electroshock seizure (MES) model. Results indicate that the combinations of TPM and GBP at the fixed-ratios of 2:1, 1:1, 1:2, 1:4 and 1:8...

The genotoxic potential of total particulate matter (TPM) from mainstream smoke (MS) and sidestream smoke (SS) of Indian smoking products, namely cigarettes and bidis, as well as a brand of US cigarettes, was studied by determining the levels of bulky aromatic DNA adducts in mouse tissues. TPM from MS or SS of various smoking products [equal weights (2.5 mg) or the amount derived from equal (0....

In this paper, a comprehensive mathematical model for designing an electric power supply chain network via considering preventive maintenance under risk of network failures is proposed. The risk of capacity disruption of the distribution network is handled via using a two-stage stochastic programming as a framework for modeling the optimization problem. An applied method of planning for the net...

Aircraft is a system that requires high reliability levels throughout flights. Preventive maintenance procedures are applied to maintain this reliability at an optimum level. The higher frequency of preventive maintenance applications means higher reliability level; however, very frequent application of preventive maintenance is not economical though. In order to obtain optimum benefit, this ma...

1. Total energy variation vs. twisting aryl rings in TPM and PTM molecules Fig. 1 The three aryl rings of the triphenylmethyl (TPM), (a) and perchloro-triarylmethyl (PTM), (b) TAM derivatives were systematically twisted from 20 to 90 degrees while relaxing the rest of the molecular structure by constrained optimizations. These calculations were done using the PBE0 hybrid functional 1 and the 6-...

Ensuring reliability as the electrical grid morphs into the “smart grid” will require innovations in how we assess the state of the grid, for the purpose of proactive maintenance, rather than reactive maintenance; in the future, we will not only react to failures, but also try to anticipate and avoid them using predictive modeling (machine learning and data mining) techniques. To help in meetin...

In industries, Preventive Maintenance (PM) is not a new practice to minimise the sudden breakdown of production machine. PM will be performed at predetermine intervals to provide a balance between failure cost and component utilisation (aging). However, most of PM interval is based on experience or original equipment manufacturer (OEM) recommendations. Consequently, the benefits from PM are not...

In this research, a developed mathematical model is proposed to optimize the preventive maintenance age and lot size for a single-unit production system producing a single item. The system is assumed to start in an in-control state producing items of acceptable quality and then after a period of production time the system may shift to an out-of-control state producing non-conforming items. The ...