The pattern VEP is frequently abnormal in multiple sclerosis. In this disease the VEP latency is prolonged and the amplitude is reduced. The use of the VEP amplitude in diagnosis is limited because of the large interand intrasubject variability and low signal-to-noise ratio (SNR). Goal of this project is to improve the SNR of VEP’s with alternative averaging procedures, and to investigate wheth...

Evoked potentials (EPs) are observed in motor cortical local field potentials (LFPs) during movement execution (movement-related potentials [MRPs]) and in response to relevant visual cues (visual evoked potentials [VEPs]). Motor cortical EPs may be directionally selective, but little is known concerning their relation to other aspects of motor behavior, such as task timing and performance. We r...

Motion-onset visual evoked potentials (VEPs) were elicited by low spatial frequency chromatic isoluminant gratings presented in a central 7 degrees circular field. The chromatic composition of the stimuli was varied so as to modulate along different axes in colour space. For slow speeds (<5 degrees/s) changing the chromatic axis induced large response differences between the S- and L/M-cone VEP...

Though useful from a clinical and practical standpoint uniform, large-field chromatic stimuli are likely to contain luminance contributions from retinal inhomogeneities. Such contribution can significantly influence psychophysical thresholds. However, the degree to which small luminance artifacts influence the chromatic VEP has been debated. In particular, claims have been made that band-pass t...

Recently, a forward-model simulation study demonstrated that the upper and lower visual field projections to extrastriate visual cortical areas V2 and V3 have polarity-inverted electrical scalp projections, a property famously associated with potentials generated in primary visual cortex (V1) (Ales et al., 2010a). The authors use this finding, along with other findings from fMRI-constrained sou...

Recently, electroencephalogram-based brain-computer interfaces (BCIs) have attracted much attention in the fields of neural engineering and rehabilitation due to their noninvasiveness. However, the low communication speed of current BCI systems greatly limits their practical application. In this paper, we present a high-speed BCI based on code modulation of visual evoked potentials (c-VEP). Thi...

PURPOSE Although cortical contrast adaptation has been extensively studied with both psychophysical and electrophysiological techniques, little is known about retinal contrast adaptation in humans. METHODS Retinal and cortical long-term contrast adaptation was assessed with simultaneous measurement of pattern electroretinogram (PERG) and cortical visual evoked potentials (VEPs). This study in...

This study compared retinotopic map identification in primary visual cortex (V1) using: (i) functional magnetic resonance imaging (fMRI) and (ii) visual evoked potentials (VEPs) coupled with dipole source localization (DSL). A multielectrode array was used to record VEPs while subjects viewed a flickering dartboard pattern modulated by a 16-bit m-sequence. The stimulus preferentially activates ...

Over the last two decades, the hypothesis of a magnocellular deficit in dyslexia has raised considerable interest and controversy. Using an electrophysiological procedure (visual evoked potentials, VEP), we compared magnocellular and parvocellular contrast and spatial frequency-response functions between phonological dyslexics (n = 16) and a typical reading group (n = 12) matched for age and so...

It is generally assumed that there is no sizable proportion of motion detectors in the primate retina. To test this specifically for humans, visual evoked potentials (VEPs) and electroretinograms (ERGs) were recorded simultaneously to visual motion onset (9.3 degrees /s) of an expanding or contracting 'dartboard'. The degree of motion-specific responses in cortex and retina was assessed by test...