anatomy: middle cranial fossa mainly floored by sphenoidal bone and located post. to innominate bone or lesser wing and ant. to temporal bone. main foramens are located in deep part, bilateral to sellae are orbital fissures, optic canals, foramen rotundom, ovale and spinosum, foramen lacerum also meckle cave or trigeminal impression and carotid canal. this fossa is like a butterfly in shape. le...

New therapies are needed to improve survival for patients with Ewing sarcoma. Over the past decade, camptothecin agents such as topotecan and irinotecan have demonstrated activity against Ewing sarcoma, especially in combination with alkylating agents. Previous studies have shown camptothecin-based combinations to be tolerable outpatient strategies that are attractive for salvage therapy. This ...

We report a case of primary extraosseous Ewing sarcoma (EES) of the lung in a four-year-old child. In the literature, there are only a few case reports of EES located in the thorax.

Objective. The goal of this study was to review the current literature on the biology of Ewing's sarcoma, including current treatments and the means by which an understanding of biological mechanisms could impact future treatments. Methods. A search of PubMed and The Cochrane Collaboration was performed. Both preclinical and clinical evidence was considered, but specific case reports were not. ...

The Clavicle is a rare primary site for Ewing sarcoma (ES). We report one case of patient with clavicular ES under our tracking and review the related literatures on management of this rare tumor. The patient was age of 35 years and was non metastatic at presentation. The patient received chemotherapy before and after the surgery. Claviculectomy was used. The patient had good functional outcome...

Background. Comorbidity is an important prognostic factor for survival in different cancers; however, neither the prevalence nor the impact of comorbidity has been investigated in bone sarcoma. Methods. All adult bone sarcoma patients from western Denmark treated at the Aarhus Sarcoma Centre in the period from 1979 to 2008 were identified through a validated population-based database. Charlson ...

BACKGROUND This study aimed to examine the surgical, oncologic, and developmental results of infants and children undergoing extirpation of skull base tumors. METHODS Sixty-seven children aged 0.5 to 18 years (mean, 11 years) who were operated on during a 6-year period made up the study cohort. Eighteen cases (27%) involved malignant tumors, and 49 (73%) involved benign tumors. The most commo...

Malignant fibrous histiocytoma (MFH) is an aggressive soft tissue sarcoma occurring in the late adulthood. It may rarely arise as a primary neoplasm in bone, but usually in the long bones and accounts for less than 1% of the malignant tumors of bone. Its presentation in the facial bones and skull is extremely rare. Malignant fibrous histiocytoma of bone is a highly malignant tumor that recurs, ...

A 21-year-old male with a 2-year diagnosis of chronic myeloid leukemia in complete hematologic and cytogenetic responses was admitted to hospital with drowsiness, headache and seizures. Laboratory evaluation disclosed leucocitosis with 19.0% of peripheral blasts. Brain magnetic resonance imaging (MRI) (Figure 1) corroborated the diagnosis of granulocytic sarcoma (GS) in blast crisis. MRI perfor...