BACKGROUND AND PURPOSE Wilson's disease (WD), also known as hepatoleticular degeneration (HLD), is a rare autosomal recessive genetic disorder of copper metabolism, which causes copper to accumulate in body tissues. In this study, rats fed with copper-laden diet are used to render the clinical manifestations of WD, and their copper toxicity-induced organ lesions are studied. To investigate meta...

In order to identify channels involved in membrane depolarization, Ulva compressa was incubated with agonists of TRP channels C5, A1 and V1, and the level of intracellular calcium was detected. Agonists of TRPC5, A1 and V1 induced increases in intracellular calcium at 4, 9, and 11 min of exposure, respectively, and antagonists of TRPC5, A1, and V1 corresponding to SKF-96365 (SKF), HC-030031 (HC...

Relatively little is known about the individual steps in intestinal copper absorption and whether or how they may be regulated. Polarized Caco-2 cell monolayers with tight junctions offer an already tested model in which to study intestinal metal transport. This model was used to examine potential effects of cellular copper availability on copper absorption. Uptake and transport were determined...

hyperandrogenism affects 2-6% of all women. hypertension is one of disturbances which is related to androgen excess. higher intakes of vitamin c and vitamin e have been associated with lower blood pressure. tho investigate the effect of these vitamin supplementation on blood pressure in hyperandrogenic women, a randomized, double-blind, placebo-controlled study was designed on 56 women 18-54 ye...

The copper-catalyzed and iodosylbenzene-mediated aziridination of (S)-N-(9phenylfluorenyl)allylglycine tert-butyl ester 10 led to the isolation of the corresponding aziridine 13 in 28% yield (65% based on consumed starting material). The (2S,4S) isomer was preferentially formed with a diastereomeric excess of 36%.

Down-regulation of copper transporter 1 (CTR1) reduces uptake and sensitivity, whereas down-regulation of CTR2 enhances both. Cisplatin (DDP) triggers the rapid degradation of CTR1 and thus limits its own accumulation. We sought to determine the effect of DDP and copper on the expression of CTR2. Changes in CTR1 and CTR2 mRNA and protein levels in human ovarian carcinoma 2008 cells and ATOX1(+/...

In marine areas throughout the world where recreational boats are densely located, concentrations of copper in the water are being found to be in excess of government standards, due to the hull coatings used on these boats. Copper-based hull coatings are intended to be antifouling in that they retard the growth of algae, barnacles and tubeworms; but alternatives exist that can eliminate the har...

Zinc and copper were histochemically localized in rat ocular tissues. Zinc was demonstrated by the dithizone method, and copper by the rubeanic acid and rhodanine methods. The retinal photoreceptor's outer segment showed the presence of zinc, but no zinc reaction was seen in other parts of the retina or other ocular tissues, even in rats fed excess zinc. It seems that photoreceptor cells contai...

A 66-year-old woman with a history of obesity status post–gastric bypass presented with pancytopenia and no evidence of myeloneuropathy. A bone marrow biopsy was performed to exclude myelodysplastic syndrome (MDS) and showed no excess blasts and several vacuolated granulocytic (red arrow) and erythroid (yellow arrows) precursors with occasional megaloblastic change. Folate and vitamin B12 level...