Abstract Objective The mini-Balance Evaluation Systems Test (BESTest) is a balance measure for assessment of the underlying physiological systems control in adults. Evaluations test–retest reliability mini-BESTest larger samples people with multiple sclerosis (MS) are lacking. purpose this study was to investigate total and section sum scores individual items mild moderate overall MS disability...

BACKGROUND Inconsistent results have been obtained with regard to headache comorbidity in multiple sclerosis (MS). OBJECTIVE Investigate the one-year prevalence of migraine and tension-type headache (TTH) in Norwegian MS patients and relate this to clinical parameters. METHODS A questionnaire concerning headache was administered to 756 MS patients and 1090 controls and used to determine the...

BACKGROUND Sensory and motor dysfunction in multiple sclerosis (MS) is often assessed with rating scales which rely heavily on clinical judgment. Quantitative devices may be more precise than rating scales. OBJECTIVE To quantify lower extremity sensorimotor measures in individuals with MS, evaluate the extent to which they can detect functional systems impairments, and determine their relatio...

Abstract Background Brain volume loss (BVL) is widespread in MS and occurs throughout the disease course at a rate considerably greater than general population. In MS, brain correlates with predicts future disability, making BVL relevant measure of diffuse CNS damage leading to clinical progression, as well serving useful outcome evaluating therapies. The aim our study was evaluate role automat...

Objectives To investigate the correlation between the disabilities of MS patients and their cognitive impairment assessed by the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS). Methods Forty patients with definitive diagnoses of MS were selected. The correlation coefficient (r) between the Expanded Disability Status Scale (EDSS) and the neuropsychological tests of BI...

Objective To assess olfactory function using the Connecticut test and verify correlations between olfactory alteration, disease duration and the Expanded Disability Status Scale (EDSS). Methods One hundred MS patients and 100 healthy control patients responded to a questionnaire. Those with olfactory alteration underwent a facial CT to exclude other causes. Results Thirty-two percent of pat...

AIM The aims of this study were to determine the reliability, responsiveness and minimally important change score of the Multiple Sclerosis Impact Scale (MSIS)-29 physical using the Expanded Disability Status Scale (EDSS) as an anchor measure. METHODS 214 patients with multiple sclerosis (MS) (EDSS 0-8.5) had concurrent MSIS-29 and EDSS assessments at baseline and at up to 4 years of follow-u...

BACKGROUND Quantitative measures derived from magnetic resonance imaging (MRI) have been widely investigated as non-invasive biomarkers in multiple sclerosis (MS). However, the correlation of single measures with Expanded Disability Status Scale (EDSS) is poor, especially for studies with large population samples. OBJECTIVE To explore the correlation of MRI-derived measures with EDSS through ...

The aim of the study was to analyze the usefulness and side effects of treatment with interferon beta 1B (Betaferon) in patients with the relapsing-remitting form of multiple sclerosis (RRMS). The study included 32 RRMS patients that had completed two-year therapy with interferon beta 1B or were still receiving this therapy. Every six months, patients were clinically evaluated and scored by the...

BACKGROUND In patients with isolated syndromes that are clinically suggestive of multiple sclerosis, such as optic neuritis or brain-stem or spinal cord syndromes, the presence of lesions as determined by T2-weighted magnetic resonance imaging (MRI) of the brain increases the likelihood that multiple sclerosis will develop. We sought to determine the relation between early lesion volume, change...