This paper considers distributed optimisation problems with black-box functions using surrogate-assisted methods. Since the cost and their derivatives are usually impossible to be expressed by explicit due complexity of modern systems, function calls have performed obtain those values. Moreover, often expensive evaluate, therefore designers prefer reduce number evaluations. In this paper, surro...

ObjectivesWhile the United States does not have a method for assessing added therapeutic benefit of drugs, France, Canada, and Germany do. We examined most expensive drugs prescribed to Medicare Part D beneficiaries in States.MethodsWe identified ultra-expensive with annual spending that exceeded $62 794 (United GDP per capita 2018) using Prescription Drug Spending Utilization Data. used rating...