the aim of this investigation was to prepare, characterize and optimize the aceclofenac proniosomes using central composite design and carry out stability studies. three independent variables selected were molar ratio of drug to lipid (x1), surfactant loading (x2) and volume of hydration (x3). based on central composite design, 16 batches of proniosomes were prepared by slurry method and evalua...

in this study, the possibility of producing coal with less than 11% ash from tailings of flotation process was investigated. the effect of six flotation parameters: collector type, collector consumption, frother type, frother consumption, pulp density and mixing rate were studied on a sample from a tailing dam. a software based experimental design approach (dx7) was applied to determine and mod...

an analytical model is proposed and an analysis is conducted for solid oxide fuel cells with goals of higher power densities. the analytical model is designed to help optimize the size, spacing, and geome-trical shapes of current collectors. the model fully considers the ohmic, species concentration, and activa-tion polarizations. from the analysis of several cases, it is recommended that 3d pi...

water conveyance systems (wcss) are costly infrastructures in terms of materials, construction, maintenance and energy requirements. much attention has been given to the application of optimization methods to minimize the costs associated with such infrastructures. historically, traditional optimization techniques have been used, such as linear and non-linear programming. in this paper, applica...

This technical note deals with a priori estimation of efficiency of functional magnetic resonance imaging (fMRI) designs. The efficiency of an estimator is a measure of how reliable it is and depends on error variance (the variance not modeled by explanatory variables in the design matrix) and the design variance (a function of the explanatory variables and the contrast tested). Changes in the ...

Nearly every theory of causal induction assumes that the existence and strength of causal relations needs to be inferred from observational data in the form of covariations. The last few decades have seen much controversy over exactly how covariations license causal conjectures. One consequence of this debate is that causal induction research has taken for granted that covariation information i...

While experimental design for well-posed inverse linear problems has been well studied, covering a vast range of well-established design criteria and optimization algorithms, its ill-posed counterpart is a rather new topic. The ill-posed nature of the problem entails the incorporation of regularization techniques. The consequent non-stochastic error introduced by regularization, needs to be tak...

this study concerns the scope to improve water flooding in heterogeneous reservoirs. we used an existing, in-house developed, optimization program consisting of a reservoir simulator in combination with an adjoint-based optimal control algorithm. in particular we aimed to examine the scope for optimization in a two-dimensional horizontal reservoir containing a single high permeable streak, as a...

the ultrasound assisted emulsification microextraction (usaeme) method followed byinductively coupled plasma-atomic emission spectrometry (icp-aes) was used for preconcentration anddetermination of bismuth (bi), indium (in) and lead (pb) in the plant azolla filiculoides lam. calix [4] pyrrole was used as a chelating agent and tetrachloroethylene was selected as extraction solvent. the main para...

enhanced oil recovery using nitrogen injection is a commonly applied method for pressuremaintenance in conventional reservoirs. numerical simulations can be practiced for the prediction ofa reservoir performance in the course of injection process; however, a detailed simulation might takeup enormous computer processing time. in such cases, a simple statistical model may be a goodapproach to the...