This study aimed to investigate the efficacy of PRP and dextrose PRL in stifle joint arthritis rabbits.Sixteen healthy adult male rabbits were allocated into groups A (n=8) B (n=8). After induction all experimental animals, animals group treated with intra-articular injection PRP, while PRL. Pain scoring was evaluated by Simple Descriptive scale at 0d, 6d, 13d, 19d, radiographic examined Kellgr...

Autoimmune hypophysitis can be reproduced experimentally by the injection of pituitary proteins mixed with an adjuvant into susceptible mice(1). Mouse models allow us to study how diseases unfold, often providing a good replica of the same processes occurring in humans. For some autoimmune diseases, like type 1A diabetes, there are models (the NOD mouse) that spontaneously develop a disease sim...

Ligand-mediated gene induction by steroid receptors is a multistep process characterized by a dose-response curve for gene product that follows a first-order Hill equation. This behavior has classically been explained by steroid binding to receptor being the rate-limiting step. However, this predicts a constant potency of gene induction (EC(50)) for a given receptor-steroid complex, which is ch...

Experimental autoimmune encephalomyelitis (EAE) is an animal model for autoimmune central nervous system disease mediated by CD4 T cells. To examine the role of B cells in the induction of EAE, we used B10.PL (I-Au) mice rendered deficient in B cells by deletion of their mu chain transmembrane region (B10.PLmicroMT). By immunizing B10.PL and B10.PLmicroMT mice with the NH-terminal myelin basic ...

Quantitative risk assessment for skin sensitization is directed towards the determination of levels of exposure to known sensitizing substances that will avoid the induction of contact allergy in humans. A key component of this work is the predictive identification of relative skin sensitizing potency, achieved normally by the measurement of the threshold (the "EC3" value) in the local lymph no...

Studies in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS), have shown that regulatory B cells modulate the course of the disease via the production of suppressive cytokines. While data indicate a role for transforming growth factor (TGF)-β1 expression in regulatory B cell functions, this mechanism has not yet been tested in autoimmune neuroinflammatio...

This purpose of this article is to highlight the various aspects of a dynamic model of gravitational interaction proposed by the author in an earlier paper. A number of interesting results are obtained when the proposed velocity and acceleration dependent inertial induction terms are used in conjunction with an extended v ersion of Mach's principle. Universal induction results in exact equivale...

This paper proposes an experimental evaluation of various discretization schemes in three different evolutionary systems for inductive concept learning. The various discretization methods are used in order to obtain a number of discretization intervals, which represent the basis for the methods adopted by the systems for dealing with numerical values. Basically, for each rule and attribute, one...

Granulomatous experimental autoimmune thyroiditis (G-EAT) is induced by transfer of mouse thyroglobulin (MTg)-sensitized spleen cells activated in vitro with MTg and anti-IL-2R or MTg and IL-12. Previous work suggested that IL-12 was required in vitro for development of G-EAT. To determine whether IL-12 was also required during the induction and/or effector phases, DBA/1 mice with a disrupted I...