Export of mRNA from the nucleus is a central process in eukaryotic gene expression that has been implicated in several human diseases. Much of our understanding of how an mRNA is transported to the cytoplasm is derived from studies using yeast and fly models. We present here different mechanisms by which aberrant nuclear retention of mRNA can cause human disease. Emerging evidence that implicat...

In eukaryotic cells, the nuclear membrane creates a barrier between the nucleus and the cytoplasm. Whereas RNA synthesis occurs in the nucleus, they mostly function in the cytoplasm; thus export of RNA molecules from the nucleus to the cytoplasm is indispensable for normal function of the cells. The molecular mechanisms involved in each kind of cellular RNA export is gradually understood. The f...

a diversification of the country’s export structure through the concerted development of its export-oriented manufacturing capacity could offer a viable alternative, as also stipulated in the country’s second socioeconomic and cultural development plan, by increasing the resilience of its economy against external shocks, supporting employment creation and technological innovation, and adding do...

raisin is the second major export item in iranian agricultural section after pistachio. in this study, effects of exchange rate fluctuations were investigated on quantity and price of exported raisin. therefore, data of 1970 to 2008 were reviewed by time series analysis and estimated by auto-regressive distributed lag model (ardl). results show the absence of a long-term relationship between ex...

Anaerobic digestion (AD) is a robust biotechnology for the valorisation of organic waste into biogas. However, rapid decrease in renewable electricity prices requires alternative uses In this context, engineering innovative platforms bio-production chemicals from CH4 has recently emerged. The extremolyte and osmoprotectant ectoine, with market price ~1000€/Kg, industrial flagship CH4-based bio-...

Several factors contribute to nuclear mRNA export in Saccharomyces cerevisiae, including Mex67p, Mtr2p, Gle1p, Nup159p, Dbp5p, and Rip1p. Strains carrying mutations in these factors show rapid and dramatic nuclear accumulation of poly(A)(+) RNA. We have characterized two heat shock mRNAs, SSA4 and HSP104, in these mutant backgrounds; each transcript concentrates in a single intranuclear focus. ...

In the AEC (Architecture / Engineering / Construction) industry, large projects are tackled by consortia of companies and individuals, who work collaboratively for the duration of the project. Such projects are complex and the consortia members provide a range of skills to the project from its inception to completion. This document is intended to describe the design for Grid-enabling of the Pro...

A field experiment was conducted during rainy (kharif) seasons of 2020 and 2021 at the research farm ICAR-Indian Agricultural Research Institute, New Delhi to study effect nutrient weed management on crop productivity soil microbial properties in aerobic rice (Oryza sativa L.). Experiment factorial randomized complete block design replicated thrice. Nutrient factor comprised 3 levels, viz. Cont...