In the context of the supersymmetric unification model in which the mass-less sector contains extra particles beyond the ones in the minimal supersym-metric standard model, we solve mixings between quarks (leptons) and the extra particles which are closely intertwined with Yukawa hierarchies. With the assumption that the unification gauge group G includes SU (2) R , it is shown that the non-tri...

In the context of the supersymmetric uni cation model in which the massless sector contains extra particles beyond those in the minimal supersymmetric standard model, we obtain mixings between quarks (leptons) and the extra particles which are closely intertwined with Yukawa hierarchies. With the assumption that the uni cation gauge group G includes SU(2)R, it is shown that the non-trivial text...

Guillain Barre Syndrome (GBS) is an autoimmune polyneuropathy. There is ascending paralysis seen in this and the onset is rapid, many a times preceded by an infection. Hyporeflex is observed and if respiratory component is involved can lead to death. Both sensory and autonomic nerve involvement is seen [1]. Matrix metalloproteinase (MMP’s) are the biggest family of extra cellular matrix degradi...

Introduction: Each year in the United States alone, approximately 11,000 individuals suffer from spinal cord injuries [1]. In order to help these individuals, various materials for neural scaffolds are being explored. These materials must mimic the extra-cellular matrix of the spinal cord to help promote cell differentiation and growth for proper recovery. The extracellular matrix is composed o...

Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the inherent capacity of cells to create highly sophisticated supramolecular assemblies. However, in dilute ex vivo microenvironments, prolonged culture time is required to develop an extracellular matrix-rich implantable device. ...

Magnetic relaxation has been used extensively to study and characterize biological tissues. In particular, spin-lattice relaxation in the rotating frame (T(1rho)) of water in protein solutions has been demonstrated to be sensitive to macromolecular weight and composition. However, the nature of the contribution from low frequency processes to water relaxation remains unclear. We have examined t...

We have previously reported that 8-epipuupehedione, a synthetic derivative of sesquiterpenes found in several kinds of sponges, is a potent inhibitor of angiogenesis. Here, we show that 8-epipuupehedione is also a potent anti- leukaemic compound, targeting three hallmarks of malignancy: proliferation, survival and extra-cellular matrix re-modelling. To fulfil this goal, we use the HL-60 promyeo...