The most promising approach in Tissue Engineering involves the seeding of porous, biocompatible/biodegradable scaffolds, with donor cells to promote tissue regeneration. Additive biomanufacturing processes are increasingly recognized as ideal techniques to produce 3D structures with optimal pore size and spatial distribution, providing an adequate mechanical support for tissue regeneration whil...

Linear friction welding (LFW) is a solid-state welding process that has been thoroughly investigated for chain welding in recent years in order to replace the currently in use Flash Butt Welding (FBW) process. Modelling has proven to be an indispensable tool in LFW, thus providing necessary insight to the process, regardless of its final application. This article describes a 3D model developed ...

This paper presents an algorithm for generating the Medial Axis Transform (MAT) of 3D objects with free form boundaries that are obtained by extrusion along a line or revolution about an axis. The algorithm proposed uses the exact representation of the part and generates an approximate rational spline description (to within a defined tolerance) of the MAT. The algorithm uses the 2D MAT of the p...

i ntroduction: apical debris extrusion (de) subsequent to root canal instrumentation, is one of the most important causes of endodontic flare-ups. the aim of this study was to compare the amount of de after root canal instrumentation using nickel-titanium (niti) hand files with step-back manual technique or installed on reciprocating handpiece. methods and materials: this study was conducted on...

objectives: during root canal preparation, apical extrusion of debris can cause inflammation, flare-ups, and delayed healing. therefore, instrumentation techniques that cause the least extrusion of debris are desirable. this study aimed to compare apical extrusion of debris by five single-file, full-sequence rotary and reciprocating systems. materials and methods: one hundred twenty human mandi...

Reasons for intrastromal corneal ring segment explantation In their recent article, Ferrer et al. report that 57 of 250 implanted intrastromal corneal ring segments (ICRS) had to be explantedda rate of 22.8%. The main cause of this very high explantation rate was extrusion (48.3%). There are 2 major causes of ICRS extrusion: (1) superficial implantation of a segment and (2) a segment that is pl...

Bi-layered scaffolds with a 0°/90° lay-down pattern were prepared by melt-extrusion additive manufacturing (AM) using a poly(ester urethane) (PU) synthesized from poly(ε-caprolactone) diol, 1,4-butandiisocyanate and l-lysine ethyl ester dihydrochloride chain extender. Rheological analysis and differential scanning calorimetry of the starting material showed that compression moulded PU films wer...

This study introduces a new microscale design approach, CONVEX, based on the idea of CONtinuously Varying EXtrusion widths deposited filaments in material extrusion additive manufacturing (MEAM). The CONVEX approach breaks free from traditional 3D printing workflow filling CAD-model volume with stacked extruded constant width and height. Instead, geometry each filament is explicitly designed ov...

Transcellular Mg(2+) transport across epithelia, involving both apical entry and basolateral extrusion, is essential for magnesium homeostasis, but molecules involved in basolateral extrusion have not yet been identified. Here, we show that CNNM4 is the basolaterally located Mg(2+) extrusion molecule. CNNM4 is strongly expressed in intestinal epithelia and localizes to their basolateral membran...