The genetic influence on the response of nonpregnant nulliparous mice to foster placenta was investigated. Two highly inbred strains (BALBI cBy and C57BL/6By), their F 1 hybrids, a backcross generation, and seven recombinant-inbred strains derived from the F2 generation were tested. It was concluded that there is a genetic component to the response of female. mice to placenta in the absence of ...

2. The Committee for Medicinal Products for Veterinary Use (CVMP) previously considered triclabendazole and agreed a toxicological ADI of 0.0015 mg/kg bw (i.e. 0.09 mg/person) based on the basis of the increased postpartum mortality of the F2 generation in the two-generation rat reproduction study (NOEL equal to 0.15 mg/kg bw/day) using a safety factor of 100. A validated analytical method base...

For this review of epigenetic transgenerational inheritance, it will be useful to provide some historical context. To that end, the initial experiments from the authors’ laboratory describing the phenomenon of epigenetic transgenerational inheritance will be outlined, and issues related to investigations in this field will be discussed using these studies as an example.1 Historically, the autho...

BACKGROUND In nanoscale layered S/F1/N/F2/AF heterostructures, the generation of a long-range, odd-in-frequency spin-projection one triplet component of superconductivity, arising at non-collinear alignment of the magnetizations of F1 and F2, exhausts the singlet state. This yields the possibility of a global minimum of the superconducting transition temperature T c, i.e., a superconducting tri...

BACKGROUND Identification of cytotoxic compounds that induce apoptosis has been the mainstay of anti-cancer therapeutics for several decades. In recent years, focus has shifted to inducing multiple modes of cell death coupled with reduced systemic toxicity. The plant Sesbania grandiflora is widely used in Indian traditional medicine for the treatment of a broad spectrum of diseases. This encour...

Gunn rats, which have defects in bilirubin and 4-nitrophenol UDP-glucuronyltransferases (GT), were crossed with LA Wistar rats with a defect in androsterone GT. The F1 hybrids showed normal GT activities towards androsterone, bilirubin and 4-nitrophenol, demonstrating that Gunn and LA ('low activity') Wistar rats inherit a homozygous dominant trait for androsterone GT and bilirubin GT respectiv...

We have mapped quantitative trait loci (QTLs) for commercially important traits (stem growth and form) and an adaptive trait (spring leaf flush) in a Populus F2 generation derived from a cross between interspecific F1 hybrids (P. trichocarpa x P. deltoides). Phenotypic data were collected over a 2-year period from a replicated clonal trial containing ramets of the parental, F1, and F2 trees. Co...

Results from univariate outbred F2 interval mapping and sib-pair analyses of 12 growth and 28 carcass traits to identify QTL on SSC 2, 6, 13, and 18 were compared. Phenotypic and genetic data were recorded on a three-generation resource population including 832 F2 pigs from a cross between three Berkshire sires and 18 Duroc dams. Thirty markers with an average spacing of approximately 16 cM wer...