نتایج جستجو برای: facit
تعداد نتایج: 404 فیلتر نتایج به سال:
BACKGROUND Health Related Quality of Life (HRQOL) is impaired in hemodialysis patients and cardiac biomarkers are elevated, but their relationship is uncertain. OBJECTIVES To determine whether the cardiac biomarkers, troponin T and N terminal pro-B type natriuretic peptide (NT-proBNP), predict deterioration in the physical domains of HRQOL. DESIGN A prospective cohort study of patients in a...
Counting and classifying blood cells is an important diagnostic tool in medicine. Support Vector Machines are increasingly popular and efficient and could replace artificial neural network systems. Here a method to classify blood cells is proposed using SVM. A set of statistics on images are implemented in C++. The MPEG-7 descriptors Scalable Color Descriptor, Color Structure Descriptor, Color ...
OBJECTIVE To determine the efficacy and safety of treatment with rituximab plus methotrexate (MTX) in patients with active rheumatoid arthritis (RA) who had an inadequate response to anti-tumor necrosis factor (anti-TNF) therapies and to explore the pharmacokinetics and pharmacodynamics of rituximab in this population. METHODS We evaluated primary efficacy and safety at 24 weeks in patients e...
BACKGROUND There is an increasing requirement to assess outcomes, but few measures have been tested for advanced medical illness. We aimed to test the validity, reliability and responsiveness of the Palliative care Outcome Scale (POS), and to analyse predictors of change after the transition to palliative care. METHODS Phase 1: multicentre, mixed method study comprising cognitive and qualitat...
Background Enthesitis and dactylitis are associated with greater disease activity reduced quality of life. Results from the phase 3 randomized, placebo-controlled KEEPsAKE 1 2 studies ( NCT03675308 ; NCT03671148 ) risankizumab in active PsA showed resolution enthesitis 150 mg vs placebo at week 24. Objectives This post hoc analysis evaluated improvements patient-reported outcomes (PROs) among p...
Background Pain, fatigue and altered quality of life are frequent complaints in axial spondyloarthritis (axSpA), with an impact on disease activity evaluation, regardless radiographic or non-radiographic phenotype. No study compares face to the effects biologic DMARDs (bDMARDs) patient reported outcomes (PROs). Objectives To evaluate (bDMARDs: anti-TNF anti-IL17) three PROs (pain, fatigue, life...
This article discusses the popular Aristotelian phrase “natura non facitsaltus” using two possible approaches – a gradual evolution and a punctuated evolution. In doing so this communication shows that in whatever aspect we examine Nature, at a microscopic level we find that continuity exists. Perhaps the same occurs at macromolecular/multi-cellular levels. Nevertheless, in sexually reproducing...
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