BACKGROUND Sexual dimorphism in human brain structure is well recognised, but less is known about gender differences in white matter microstructure. We used diffusion tensor imaging to explore gender differences in fractional anisotropy (FA), an index of microstructural integrity. We previously found increased FA in the corpus callosum in women, and increased FA in the cerebellum and left super...

To assess whether Fanconi anemia (FA) patients might be at risk for acute graft-versus-host disease (AGvHD) despite using low-intensity conditionings, we retrospectively analyzed the incidence of AGvHD and its impact on outcome in 37 FA patients and 73 patients with acquired aplastic anemia (AAA) that received transplants at Saint Louis Hospital from HLA-genotypic identical siblings with simila...

Increasing evidence demonstrates that maternal folic acid (FA) supplementation during pregnancy reduces the risk of neural tube defects, but whether FA prevents preterm delivery and intrauterine growth restriction (IUGR) remains obscure. Previous studies showed that maternal lipopolysaccharide (LPS) exposure induces preterm delivery, fetal death and IUGR in rodent animals. The aim of this study...

Title of Document: REGULATION OF MILK FAT SYNTHESIS BY DIETARY FATTY ACIDS ANIL KUMAR G. KADEGOWDA PhD. 2008 Directed By: Professor, Dr. RICHARD ERDMAN, Dept. of Animal and AvianSciences, UMCP. The objectives of this thesis research were to determine the molecular mechanisms by which dietary fatty acids (FA) regulate lipogenic gene expression and milk fat synthesis. Principal component and mult...

8 A review of the literature is presented, showing that the mixed model 9 analogues of models employed in the analysis of multi-environment trials in 10 plant breeding are directly applicable to genotype × environment and related 11 problems in animal breeding. In particular, the so-called ’additive main effect, 12 multiplicative interaction’ or ’bi-linear’ models accommodate heterogeneity 13 o...

Detecting the dimension of the latent subspace of a linear model, such as Factor Analysis, is a well-known model selection problem. The common approach is a two-phase implementation with the help of an information criterion. Aiming at a theoretical analysis and comparison of different criteria, we formulate a tool to obtain an order of their approximate underestimation-tendencies, i.e., AIC, BI...

Mild hyperhomocysteinemia is a risk factor for many diseases, including cardiovascular disease. We determined the effects of insulin resistance and of type 2 diabetes on homocysteine (Hcy) metabolism using Zucker diabetic fatty rats (ZDF/Gmi fa/fa and ZDF/Gmi fa/?). Plasma total Hcy was reduced in ZDF fa/fa rats by 24% in the pre-diabetic insulin-resistant stage, while in the frank diabetic sta...

As a kind of pictographic character, Naxi pictographs character has received little academic attention. Proposing dimension reduction method of Naxi pictographs characters on the basis of LDA (Linear Discriminant Analysis), this paper thus makes an in-depth study of feature dimension reduction, an important issue in the recognition of Naxi pictographs characters. By constructing a recognition s...

In this paper we study the application of classical methods for dynamical modelling of time series to the task of decomposing multivariate time series into approximately independent source components, a task that has traditionally been addressed by Factor Analysis (FA) and more recently by Independent Component Analysis (ICA). Based on maximum-likelihood fitting of linear state space models we ...

Although formaldehyde (FA) is known to be a major allergen responsible for allergic contact dermatitis, there are conflicting reports regarding correlation between FA exposure and interleukin (IL-4) expression. To investigate whether allergic responses including IL-4 expression were induced by repeated dermal exposure to low dose FA, alterations in the luciferase signal and allergic phenotypes ...