An epidemic of infections due to group A Streptococcus haemolyticus type 12 originated in an infant with bronchiectasis, and involved children and nurses. Some of the children spread contagion; the nurses did not spread contagion. The children who spread contagion had few or no recognizable type 12 organisms in their throats; most of the nurses had type 12 predominant in their throat flora. Two...

The factor V Leiden variant, responsible for the phenomenon of activated protein C resistance, was found to be less frequent among British (0.06) and Swedish/Danish (0.15) protein C deficiency patients than previously reported in a Dutch study (0.19). In the Swedish population, a significantly increased frequency of the factor V Leiden allele was apparent in protein C deficiency patients as com...

We report a case of bilateral cavo-ilio-femoral thrombosis in an adolescent with factor V heterozygous mutation and transient antiphospholipid antibodies secondary Varicella infection.The clinical significance of finding transient antiphospholipid antibodies in the sera of infectious disease is unclear. We here report a case of bilateral cavo-ilio-femoral thrombosis in an adolescent with newly ...

1. Akar n: Thrombosis and risk factors. Turk J Hematol 2010: 27 (4) : 318-319 2. Koç Yl, Akar n: Single nucleotide polymorphisms that affect homocysteine levels in Turkish population. Clin Appl Thromb Hemost 2009; 15: 701-704 3. lyon E: Discovering rare variants by use of melting temperature shifts seen in melting curve analysis. Clin Chem 2005; 51: 1331-1332 4. Erali m, Schmidt B, lyon E, Witt...

Separation of Polycyclic Aromatic Hydrocarbons was performed by RP-HPLC using mixed micellar mobile phase. Effect of temperature, types and amounts of coorganic solvent in mobile phase on efficiency, asymmetry factor and selectivity factor showed that the appropriate condition for separation of these compounds was 3% isopropanol (V/V) as co-organic solvent in mobile phase at 40°C. Analysis of...

In 1954 Oeri et al. [1] described two young siblings with a lifelong history of a bleeding tendency related to a deficiency of both factor (F) V and FVIII. Reports of additional families in the late 1950s and 1960s [2–6] suggested that the common occurrence of FV and FVIII deficiencies was not a mere coincidence of parahemophilia and hemophilia A. This was further supported by the observation t...

BACKGROUND Role of genetic factors in etiology of preeclampsia is not confirmed yet. OBJECTIVE Gene defect frequency varies in different geographic areas as well as ethnic groups. In this study, the role of factor V Leiden mutation in the pathogenesis of preeclampsia syndrome among the pregnant population of northern shore of Persian Gulf in Iran, were considered. MATERIALS AND METHODS Betw...

BACKGROUND The factor V Leiden mutation is a genetic defect associated with an increased incidence of venous thromboembolism. When the incidence of venous thromboembolism in relatives of patients known to have the mutation outweighs the disadvantages of prophylactic strategies, family screening may be necessary. OBJECTIVE To determine the incidence of venous thromboembolism in first-degree re...