Water distribution networks consist of different components, such as reservoirs and pipes, and exist to provide users (households, agriculture, industry) with high-quality water at adequate pressure and flow. Water distribution network design optimization aims to find optimal diameters for every pipe, chosen from a limited set of commercially available diameters. This combinatorial optimization...

the purpose of this research was to formulate and systemically evaluate in-vitro and in-vivo performances of mucoadhesive propranolol hydrochloride microspheres for its potential use in the treatment of hypertension, myocardial infraction and cardiac arrhythmias. propranolol hydrochloride mucoadhesive microspheres, containing carbopol-934p as mucoadhesive polymer and ethyl cellulose as carrier ...

turning of hardened steels using a single point cutting tool has replaced the cylindrical grinding now as it offers attractive benefits in terms of lower equipment costs, shorter set up time, fewer process setups, higher material removal rate, better surface quality and elimination of cutting fluids compared to cylindrical grinding. in order to obtain desired surface quality by machining, prope...

Quad Flat No-lead (QFN) presents an excellent example of a complex substrate composed of both ductile (copper) and brittle (plastic molding compound) materials, showing clear trends of reduction in package size and the combination ductile and brittle materials in the same sawing process which creates real challenges in term of sawing quality, blade life and throughput. This paper discussed on t...

The aim of this study was to optimize topical nanoemulsions containing genistein, by means of a 23 full factorial design based on physicochemical properties and skin retention. The experimental arrangement was constructed using oil type (isopropyl myristate or castor oil), phospholipid type (distearoylphosphatidylcholine [DSPC] or dioleylphosphaditylcholine [DOPC]), and ionic cosurfactant type ...

The standard culture system for in vitro cartilage research is based on cells in a three-dimensional micromass culture and a defined medium containing the chondrogenic key growth factor, transforming growth factor (TGF)-β1. The aim of this study was to optimize the medium for chondrocyte micromass culture. Human chondrocytes were cultured in different media formulations, designed with a factori...

For the accurate analysis of possible interactive effects of chemicals in a defined mixture, statistical designs are necessary to develop clear and manageable experiments. For instance, factorial designs have been successfully used to detect two-factor interactions. Particularly useful for this purpose are fractionated factorial designs, requiring only a fraction of all possible combinations of...

For production of protease by a new strain, Serratia marcescens SB08, optimization of the fermentation medium and environmental conditions, were carried out by applying factorial design and response surface methodology. The results of factorial design showed that pH, agitation, incubation time and yeast extract were the key factors affecting protease production. The optimal cultural conditions ...

Edible mushroom species are considered as an adequate source of food in a healthy diet due to high content of protein, fiber, vitamins, and a variety of minerals. The representatives of Pleurotus genus are characterized by distinct gastronomic, nutritional, and medicinal properties among the edible mushrooms commercialized worldwide. In the present study, the growth of mycelial biomass of Pleur...