Breast and prostate cancer preferentially metastasize in the skeleton, inducing locally increased bone resorption by osteoclasts. Bisphosphonates (BPs), potent inhibitors of osteoclasts and bone resorption, are able to reduce metastatic bone lesions, but the metastasis-related cellular target molecules for BPs have not yet been identified. In osteoclasts, nitrogen-containing BPs inhibit the fun...

s i l i c i c acid column chromatography has proved very useful in the separation and isolation of many of the sterols found in the nonsaponifiable fraction of lipid mixtures (1-8). In the course of an investigation of the nonsaponifiable lipids formed from mevalonic acid-C14 by a rat ascites tumor, a highly radioactive fraction was isolated by chromatography 011 silicic acid. This fraction was...

By implementing a common and industrially used method, 30 compounds which are structurally related to geranyl acetone, nerolidol, farnesal, farnesol and farnesyl acetate were obtained. Their antimicrobial activity against Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii bacteria was investigated. Pharmacophor...

Chemical constituents and biological activities of the Mitrella kentii leaf oil were investigated in this study. Gas chromatography (GC) gas chromatography-mass spectrometry (GC-MS) used to determine chemical oil. The was evaluated for its ability inhibit prostaglandin E2 (PGE2) thromboxane B2 (TXB2) productions human whole blood using a radioimmunoassay technique. Its inhibitory effect on plat...