نتایج جستجو برای: fcγriia
تعداد نتایج: 293 فیلتر نتایج به سال:
Laboratory testing for heparin-induced thrombocytopenia (HIT) has important shortcomings. Immunoassays fail to discriminate platelet-activating from nonpathogenic antibodies. Specific functional assays are impracticable due to the need for platelets and radioisotope. We describe 2 assays that may overcome these limitations. The KKO-inhibition test (KKO-I) measures the effect of plasma on bindin...
Antibodies with antibody-dependent cellular cytotoxicity (ADCC) activity play an important role in protection against HIV-1 infection, but generating sufficient amounts of antibodies to study their protective efficacy is difficult. HIV-specific IgG can be easily and inexpensively produced in large quantities using bovine colostrum. We previously vaccinated cows with HIV-1 envelope gp140 and eli...
The balance between activating and inhibitory signals from the different FcγRs for IgG ensures homeostasis of many inflammatory responses. FCGR2C is the product of an unequal crossover of the FCGR2A and FCGR2B genes encoding the activating FcγRIIa (CD32a) and inhibitory FcγRIIb (CD32b), respectively. A single nucleotide polymorphism (SNP) in exon 3 of FCGR2C results in either expression of the ...
Heparin‐induced thrombocytopenia (HIT) is an immune‐thrombotic complication of heparin treatment caused by platelet‐activating antibodies against complexes platelet factor 4 (PF4) and (HIT antibodies). Pathogenic HIT bind to activate the monocyte Fc receptor FcγRIIa propagate a hypercoagulable state.1.Greinacher A. thrombocytopenia.N Engl J Med. 2015; 373: 252-261Crossref PubMed Scopus (320) Go...
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