Defective glucose utilization in the liver of the glucose-fed diabetic rat has been stated to be the result of at least two blocks: one, at an early stage in glycolysis, probably hexokinase; the other, in the synthesis of fatty acids from the Z-carbon-like intermediate. This conclusion was based on the following observations: (1) the conversion of C14-glucose to CO2 was depressed in the liver o...

This study aimed to determine whether orally administered ovine serum immunoglobulin (Ig) modulates aspects of immunity such as phagocytosis, lymphocyte proliferation, cytokine production, intestinal and plasma Ig concentrations in growing rats. Forty-five male Sprague-Dawley rats (n = 15/group) were used in the 21-day study, and fed a basal control diet (BD; no Ig) or two test diets: freeze-dr...

Levels of n-6, n-3, and medium-chain fatty acids (MCFA) in milk are highly variable. Higher carbohydrate intakes are associated with increased mammary gland MCFA synthesis, but the role of unsaturated fatty acids for milk MCFA secretion is unclear. This study addressed whether n-6 and n-3 fatty acids, which are known to inhibit hepatic fatty acid synthesis, influence MCFA in rat and human milk ...

Defective glucose utilization in the liver of the glucose-fed diabetic rat has been stated to be the result of at least two blocks: one, at an early stage in glycolysis, probably hexokinase; the other, in the synthesis of fatty acids from the Z-carbon-like intermediate. This conclusion was based on the following observations: (1) the conversion of C14-glucose to CO2 was depressed in the liver o...

Hydrogen sulphide (H2S), a newly identified gasotransmitter, can be endogenously produced by cystathionine gamma-lyase (CSE) in the cardiovascular system. This study investigated role of CSE/H2S system on lipid overload-induced lipotoxicity and cardiac senescence. Lipid overload rat cardiomyocyte cells (H9C2) promoted intracellular accumulation lipid, oxidative stress, mitochondrial dysfunction...

I . In the aetiopathogenesis, in Nigerians, of a degenerative neuropathy known as tropical ataxic neuropathy, chronic cyanide intoxication is believed to be the most important factor. The source of the cyanide is cassava (Manihot) and in Nigerian patients, plasma concentration of thiocyanate, a major detoxication product of cyanide, is high. 2. Since there is considerable doubt as to whether cy...