Nicotine replacement products are commonly used to promote smoking cessation, but alternative and complementary methods may increase cessation rates. The current experiment compared the short-term effects of a transdermal nicotine patch to voucher-based reinforcement of smoking abstinence on cigarette smoking. Fourteen heavy smokers (7 men and 7 women) completed the four 5-day phases of the stu...

Aim: The objective of the present research work was to formulate and compare two different kinds of penetration enhancer in transdermal patch with placebo patch using a drug (Salbutamol sulphate) and compare for in vitro drug release. Study Design: The transdermal patches of Salbutamol sulphate were prepared by solvent evaporation technique using different ratios of Hydroxy propyl methylcellulo...

Opioid intoxication in pediatrics is rare Morocco. In the children’s hospital of Rabat, it third case that has been recorded recent years. It about a boy 8 years old who after benign trauma at level back, his father attached to him patch fentanyl dosed 75 µg/h given by friend returning from abroad. After hours, found child unconscious with abnormal breathing, motivating bring back emergency roo...

OBJECTIVES We hypothesized that by enhancing parasympathetic activity, low dose transdermal scopolamine would increase heart rate variability after myocardial infarction. BACKGROUND Low heart rate variability is associated with increased mortality after acute myocardial infarction. METHODS Conventional time domain heart rate variability was measured from 24-h Holter recordings of 61 consecu...

Worldwide prevalence of type 2 diabetes is increasing with alarming proportions. Metformin is the first-line oral antidiabetic drug of choice for the treatment of type 2 diabetes. The objectives of the present study were to develop Metformin solid lipid nanoparticles (M-SLN) and incorporate it in the transdermal patches. M-SLN was evaluated for Particle size, Zeta potential, Surface morphology ...

Transdermal therapeutic systems (TTS) belong to the widely used methods of drug administration, which allow rate-controlled drug delivery and avoidance of first-pass metabolism in the liver Beside scopolamine, nitroglycerin (glyceryl trinitrate), nicotine, clonidine and fentanyl, also transdermal delivery of sex steroids for hormone replacement therapy and contraception is a well-known and popu...

There has been a continuously increased interest during recent years in the use of topical vehicle systems that can enhance drug penetration through the skin barrier into the skin or the systemic circulation. In particular, transdermal drug delivery (TDD) is an attractive alternative to conventional oral and injectable dosage forms. Since its introduction about twenty years ago, TDD has generat...

Transdermal administration offers a non-invasive and convenient method for paediatric drug delivery. The competent skin barrier function in term infants and older children limits both water loss and the percutaneous entry of chemicals including drugs; but the smaller doses required by children eases the attainment of therapeutic concentrations. Transdermal patches used in paediatrics include fe...