One of our goals is to understand the mechanisms that deposit mineral within collagen fibrils, and as a first step we recently determined the size exclusion characteristics of the fibril. This study revealed that apatite crystals up to 12 unit cells in size can access the water within the fibril, whereas molecules larger than a 40-kDa protein are excluded. Based on these observations, we propos...

BACKGROUND An increase in aortic stiffness, as reflected by an increase in pulse wave velocity (PWV), is an important predictor of cardiovascular mortality in dialysis patients. Decreased serum concentration of calcification inhibitor, such as fetuin-A, is inversely related to mortality in haemodialysis patients. Our aim is to investigate the factors associated with aortic stiffness and its cha...

(r1⁄4 0.495; P1⁄4 0.024). There were no relationships between IL-6 changes and the main mineral metabolism related parameters. Our results agree with previous experimental findings [4] and point to the efficacy of calcimimetic drugs for the control of uraemic SHP. It was unexpected that 6 months of cinacalcet treatment resulted in highly significant increases in OPG and decreases in Fetuin-A se...

Hepatoprotective effect of gallic acid against type 2-induced diabetic liver injury in male rats through modulation fetuin-A and GLP-1 with involvement ERK1/2/NF-κB Wnt1/β-catenin signaling pathways

BACKGROUND Cardiovascular morbidity and mortality are massively increased in patients with chronic kidney disease (CKD). Sevelamer hydrochloride has been shown to attenuate cardiovascular calcifications in CKD and end-stage renal disease (ESRD) patients. We assessed how sevelamer hydrochloride influences the evolution of serum fetuin-A and other serological factors predicting cardiovascular out...

Non‑alcoholic fatty liver disease (NAFLD) remains the leading nosology among hepatic diseases around world. Its complex pathogenesis is not still clearly understood. Besides metabolic changes one of potential mechanisms NAFLD development in hepatokines, fetuin‑A particular, secretion and metabolism.
 Objective — to determine role progression NAFLD.
 Materials methods. The study enroll...

Fetuin-A and adiponectin display noteworthy affiliations, bolstered by recent prove, with metabolic disorder, obese type 2 diabetes including hyperglycemia, central weight insulin resistance as the most components, but their natural capacities are inverse. The point of this consider was to confirm role fetuin-A touchy marker for assessment diabetes. In analytical cross-sectional study, 100 cont...

BACKGROUND The role of interleukin (IL)-6 and IL-18 in induction of the inflammatory reaction underlying arteriosclerosis, and protective effect of an anti-inflammatory cytokine IL-10 in this process, have been confirmed by experimental and clinical observations. A systemic inflammatory reaction marker, C-reactive protein (CRP), is known to be associated with the induction of IL-6 and IL-18 rel...

Fetuin-A (ahsg) is a Major Serum Adhesive Protein that Mediates Growth Signaling in Breast Tumor Cells. Amos M. Sakwe, Rainelli Koumangoye, Shawn J. Goodwin, and Josiah Ochieng Department of Biochemistry and Cancer Biology Meharry Medical College Nashville TN; Department of Cancer Biology, Vanderbilt University, Nashville TN. Running title: Fetuin-A, a cell attachment and growth factor in serum...