Motivation: The function of an unknown biological sequence can often be accurately inferred if we are able to map this unknown sequence to its corresponding homologous family. Currently, discriminative approach which combines support vector machine and sequence similarity is recognized as the most accurate approach. SVM-Fisher and SVM-pairwise methods are two representatives of this approach, a...

Abstract: In this paper the stochastic complexity criterion is applied to estimation of the order in AR and ARMA models. The power of the criterion for short strings is illustrated by simulations. It requires an integral of the square root of Fisher information, which is done by Monte Carlo technique. The stochastic complexity, which is the negative logarithm of the Normalized Maximum Likelihoo...

Kunert and Martin (2000) determined optimal and efficient block designs in a model for field trials with interference effects, for block sizes up to 4. In this paper we use Kushner’s method (Kushner, 1997) of finding optimal approximate designs to extend the work of Kunert and Martin (2000) to optimal designs with five or more plots per block. We give an overall upper bound at,b,k for the trace...

We revisit the problem of computing submatrices of the Cramér-Rao bound (CRB), which lower bounds the variance of any unbiased estimator of a vector parameter θ. We explore iterative methods that avoid direct inversion of the Fisher information matrix, which can be computationally expensive when the dimension of θ is large. The computation of the bound is related to the quadratic matrix program...

In this paper we introduce a projection method for the space of probability distributions based on the differential geometric approach to statistics. This method is based on a direct L2 metric as opposed to the usual Hellinger distance and the related Fisher Information metric. We explain how this apparatus can be used for the nonlinear filtering problem, in relationship also to earlier project...

Fisher randomization tests for Neyman’s null hypothesis of no average treatment effects are considered in a finite population setting associated with completely randomized experiments with more than two treatments. The consequences of using the F statistic to conduct such a test are examined both theoretically and computationally, and it is argued that under treatment effect heterogeneity, use ...

Lie symmetry group method is applied to study the Fisher-Kolmogorov equation. The symmetry group is given, and travelling wave solutions are obtained. Finally the conservation laws are determined.