Transplantation of neural stem cells (NSCs) in the injured spinal cord has been shown to improve functional outcome. However, the influence of NSCs transplantation on the sensory function and analgesic behaviors has not been elucidated yet. Here, we investigated whether transplanted NSCs would improve sensory function in rats subjected to complete cord transection (T10) and explore the underlyi...

BACKGROUND Chronic abuse of opiates induces dependency, but the neurobiological mechanisms of this event remain unclear. The aim of this study was to evaluate the effects of intracerebroventricular of venlafaxine on the morphine dependence and pain perception. METHODS A total of 80 adult male rats were divided into two major groups: (1) 40 of them was divided into groups of positive control (...

In the present study the effects of both CCK receptor agonists and antagonists on antinociception induced by morphine in the tail-flick test have been evaluated. M orphine induced dose-dependent antinociception in mice. The response of morphine was potentiated by sulfated cholecystokinin-8 (CCK-8S) but not by unsulfated cholecystokinin-8 (CCK-8U). The CCK receptor antagonists MK-329 and L-...

extracts obtained from the petals of rosa damascena (rosaceae) are used in iranian folk medicine as remedies for the treatment of some inflammatory diseases. in this study the hydroalcoholic extract and essential oil of the plant were investigated for its possible anti-inflammatory and analgesic activities. the extract was administered at the doses (p.o.) of 250, 500 and 1000?mg/kg and the dose...

introduction: methadone has been used as a drug to detoxify opioid tolerance. naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. on the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in drinking...

extracts obtained from the aerial parts of stachys lavandulifolia (lamiaceae) are used in iranian folk medicine as remedies for the treatment of various painful and inflammatory diseases. for evaluation of its probable analgesic and anti-inflammatory effects, hydroalcoholic, polyphenolic and boiled extracts of the aerial parts of the herb were prepared and their analgesic effects were studied i...

Este estudo tem como objetivo analisar os limites e as possibilidades que o Plano de Ações Articuladas - PAR traz para a gestão da Educação municípios do estado Rio Grande Sul pertencentes à AMZOP (Associação dos Municípios Zona Produção). De abordagem qualitativa (FLICK, 2009; 2012), casos múltiplos (YIN, 2001; TRIVIÑOS, 1987), foram utilizados questionários Google coleta dados, enviados via l...