A nonlocal interface equation is derived for two-phase fluid flow, with arbitrary wettability and viscosity contrast, c=(mu(1)-mu(2))/(mu(1)+mu(2)), in a model porous medium defined as a Hele-Shaw cell with random gap b(0)+delta b. Fluctuations of both capillary and viscous pressure are explicitly related to the microscopic quenched disorder, yielding conserved, nonconserved, and power-law corr...

BACKGROUND Aquaporins (AQP) are water channel proteins that enable fluid fluxes across cell membranes, important for homeostasis of the tissue environment and for cell migration. AQP1 knockout mouse models of human cancers showed marked inhibition of tumor-induced angiogenesis, and in pre-clinical studies of colon adenocarcinomas, forced over-expression of AQP1 was shown to increase angiogenesi...

Urinary trypsin inhibitor (UTI) has a multipotent inhibitory effect on proteases such as trypsin, chymotrypsin, plasmin, human leukocyte elastase, or hyaluronidase. UTI can bind easily to its receptors on various types of tumor cells (human ovarian cancer HOC-I cells, human choriocarcinoma SMT-cc1 cells, and murine Lewis lung carcinoma 3LL cells). Our results show that the UTI receptors of some...

Tumor Cell Intravasation Minireview Alu-cidated: The Chick Embryo Opens the Window level, it is a dramatic breach of the normal situation of organizational stability of tissues. However, it should be noted that vascular dissemination is utilized to a limited extent during normal embryogenesis for the correct positioning of cells arising in one location and whose final location is in a distant t...

objective: the purpose of this pilot study was to determine whether the mri and biomarkers human epididymis protein 4 (he 4 ) and ca 125 correlate with depth of myometrial invasion, histologic grade, cervical involvement and nodal metastases in patients with endometrioid adenocarcinoma of the uterus. materials and methods: this was a prospective, observational study in women with biopsy-proven ...

BACKGROUND During invasion of human skin by schistosome blood fluke larvae (cercariae), a multicellular organism breaches the epidermis, basement membrane, and dermal barriers of skin. To better understand the pathobiology of this initial event in schistosome infection, a proteome analysis of human skin was carried out following invasion by cercariae of Schistosoma mansoni. METHODOLOGY AND RE...

Introduction: Laryngeal squamous cell carcinoma (SCC) can invade the thyroid gland leading to unnecessary thyroidectomies with subsequent hypothyroidism and hyperparathyroidism. Thus, clinicopathological variables should be defined in order to predict thyroid gland invasion preoperatively.   Materials and Methods: We performed a retrospective analysis of 1,465 patients with laryngeal SCC referr...