UNLABELLED Middle ear cholesteatomas are characterized by the presence of stratified squamous epithelium in this cavity with highly invasive properties causing bone destruction and it may lead to complications. AIM To study the histopathological features in acquired cholesteatomas of the middle ear, correlating this data with patient age. STUDY DESIGN clinical and experimental cross-section...

Survivin is a recently discovered member of the family of proteins that inhibits apoptosis. This anti-apoptotic compound can be detected in most types of cancer and expression is associated with a poor prognosis. We, immunohistochemically, investigated the expression of survivin in breast carcinomas and intraductal epithelial neoplasia of the breast to determine whether expression of this prote...

Nonfocal liver biopsy may be required to diagnose or stage diffuse parenchymal dis• ease such as cirrhosis, viral hepatitis, autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, hemachromatosis, and Wilson’s disease. Focal liver biopsy may be necessary to diagnose or stage primary or secondary hepatic • malignancy and to differentiate malignancy from benign hepatic m...